The research focuses on a anti-slip differential. By collecting related patents classified and analysis them, it is discovered that most anti-slip differential using on cars. Few anti-slip differential apply on scooters for handicapped people. In order to make the scooter more safety, I will make research on scooter in the market. I will provide two design methods, and then utilize the dimension synthesis, motion simulation, interfere check, to check whether its in the expected mechanism. The first design method will prove their anti-slip capability in an experiment. And the second design method will use Ansys 11.0 computer software to verify the structure. In order to understand design's practicability, press close to the handicapped user's demand even more.