- 學位論文
聚麩胺酸/三鈣矽酸鹽複合骨水泥之研究
Study of γ-Polyglutamic Acid/Tricalcium Silicate Composite Bone Cement
摘要
骨水泥是一種用於填充骨與植入骨間隙或骨腔，並具有自凝特性的生醫材料，因具備可注射性及可塑性，可被填補入不同尺寸的骨缺陷中。 三鈣矽酸鹽(C3S)為波特蘭水泥的主要成分，在生醫材料方面也應用廣泛，具有良好的生物相容性及自固化能力因此可作為骨水泥，固化後擁有一定的機械強度但容易碎裂。聚麩胺酸(γ-PGA)為天然高分子，無毒、生物相容性高並可食用。為了改善三鈣矽酸鹽骨水泥的物理性質，本研究添加聚麩胺酸製備複合骨水泥並測試其性質。 本實驗以溶膠凝膠法合成三鈣矽酸鹽，以1400oC、4小時煆燒膠體材料得到粉末，經過研磨，過400號篩網，以不同比例混和聚麩胺酸鈣鹽均勻攪拌後，粉末與10 wt% NaH2PO4水溶液以1:2之水粉比製成複合骨水泥，之後進行材料特性分析及其生物相容性評估。因聚麩胺酸含有羧基，當與三鈣矽酸鹽結合，進行螯合作用，本研究評估其作為優良骨水泥的可行性。
並列摘要
Bone cement, a biomaterial with self-curing properties, is used to fill bone defects of different sizes for its injectability and plasticity. Tricalcium silicate (C3S), the main component of Portland cement, is also widely used in terms of biomedical materials. It has good biocompatibility and ability of self-curing to serve as bone cement as a result. And after curing it has certain mechanical strength but easily being broken. γ-PGA is a natural, non-toxic, highly biocompatible and edible polymer. In order to improve the physical properties of tricalcium silicate cement, in the study we prepared γ-polyglutamic acid/tricalcium silicate composite bone cement and tested its properties. Tricalcium silicate was synthesized by sol-gel method. The C3S powder was grinded and calcined in electrically heated furnace in an air atmosphere at 1400oC for 4h. The C3S powder was passed through a No. 400 sieve and mixed with different proportions of γ-PGA. With a ratio of powder/liquid 2:1, the powder was mixed with 10-wt % NaH2PO4 solution to make of the composite bone cement. Due to PGA containing carboxyl, the chelation reaction carried out when combined with tricalcium silicate. After a serious of materials characteristics and biocompatibility evaluations, the potential of the composite to be an ideal bone cement was investigated.