生醫用鈦基合金之應用研究:生物相容性特徵

Research of biomedical titanium-based alloy: Biocompatibility characteristics

張國棟(KUO-TUNG CHANG)

指導教授 ： 羅金文

臺北醫學大學/口腔醫學院/醫療器材產業碩士專班/碩士(2013年)

https://doi.org/10.6831/TMU.2013.00120

摘要

鈦金屬是一種具備良好強度與重量比之材料，諸多研究亦指出其高疲勞強度與抗蝕性非常適合做為人體植入物，而被廣泛應用於生醫材料上。然而鈦金屬之所以具備極佳生物相容性的主要原因與其表面氧化層有關，本實驗利用電漿鈦金屬表面改質，並使其表面呈現奈米化結構，藉此表面處理進而提高鈦金屬之生物相容性。同時針對經過電漿處理之鈦金屬，根據ISO 10993 之規範進行生物相容性測試，希望其奈米氧化層TiO2 可以增加蛋白質貼附、提高細胞貼附與血液反應，藉此確認經過電漿氧化處理之鈦金屬可加速骨整合之效果。

關鍵字

電漿處理 ； 表面改質 ； 奈米氧化層

並列摘要

Titanium is a metal with good strength to weight ratio of materials, many studies also point out the high fatigue strength and corrosion resistance is very suitable as human implants, been widely used in biomedical materials. However, titanium has excellent biocompatibility of the main reasons why the surface oxide layer and its related plasma surface modification of titanium, nano-based surface display and its structure, to surface treatment and to improve the biocompatibility of titanium. Through this project for the titanium plasma-treated, according to the norms ISO 10993 biocompatibility testing, hope that their nano-TiO2 oxide layer can increase the protein attached to improve the cell-attached and blood effects, to confirm through the plasma oxidation of titanium metal can accelerate the process of bone integration effect.

並列關鍵字

plasma ； surface modification ； nano-TiO2 oxide

參考文獻

[1] Kumar S., Narayanan T.S.N. Sankara, Electrochemical characterization of β-Ti alloy in Ringer’s solution for implant application, J. Alloys Compd. 479 (2009) 699-703.

[2] Niemeyer T.C., Grandini C.R., Pinto L.M.C., Angelo A.C.D., Schneider S.G., Corrosion behavior of Ti–13Nb–13Zr alloy used as a biomaterial, J. Alloys Compd. 476 (2009) 172-175.

[3] Han J.H., Park D.H., Bang C.W., Yi S., Lee W.H., Kim K.B., Sn effect on microstructure and mechanical properties of ultrafine eutectic Ti–Fe–Sn alloys, J. Alloys Compd. 483 (2009) 44-46.

[4] Peng P.W., Ou K.L., Chao C.Y., Pan Y.N., Wang C.H., Research of microstructure and mechanical behavior on duplex (α + β) Ti–4.8Al–2.5Mo–1.4V alloy, J. Alloys Compd. 490 (2010) 661–666.

[5] Chang M.C., Luo C.W., Huang M.S., Ou K.L., Lin L.H., Cheng H.C., High-temperature microstructural characteristics of a novel biomedical titanium alloy, J. Alloys Compd. 499 (2010) 171–175.