二氧化鈦層對鈦合金之材料性質與血液相容性研究

Research of the material properties and blood compatibility of TiO2 layers on titanium alloy

陳忠明(CHUNG-MING CHEN)

指導教授 ： 林永和

臺北醫學大學/口腔醫學院/醫療器材產業碩士專班/碩士(2014年)

摘要

無資料

關鍵字

鈦

並列摘要

Nanoporous titanium dioxide (TiO2) layers were prepared on a Ti substrate by
using oxygen plasma-immersion ion implantation (oxygen PIII). The surface
chemical states, structure, and morphology of the layers were studied using X-ray
photoelectron spectroscopy, X-ray diffraction, Raman microscopy, and atomic force
microscopy. The mechanical properties, such as the Young's modulus and hardness,
of the layers were investigated using nanoindentation testing. The Ti4+ chemical state
was determined to be present on oxygen-PIII-treated surfaces, which consisted of
nanocrystalline TiO2 with a rutile structure. A nanoporous structure was observed on
the layers after oxygen PIII treatment, and compared with an untreated Ti
substrate, the treated specimens exhibited decreased Young's moduli and hardness,
which corresponded to the percentage of the porosity. Parameters indicating the
blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time
and platelet adhesion and activation, were studied in vitro. Clotting time assays
indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of
the untreated Ti substrate, which was associated with decreased fibrinogen adsorption.
In conclusion, the blood compatibility of Ti implants can be improved using oxygen
PIII.

並列關鍵字

titanium, oxygen plasma-immersion ion implantation (oxygen PIII), clotting time, platelet activation

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