成人之飲食模式、營養狀況、生活型態和貧血相關變量之間的關聯：2001年至2015年人口研究

Association between Dietary Pattern, Anthropometric Status, Lifestyle, and Anemia Related Biomarkers among Adults: A Population-Based Study from 2001 to 2015

萊帝(Rathi Paramastri)

指導教授 ： 趙振瑞

共同指導教授 ： 徐建業(Chien-Yeh Hsiu)

臺北醫學大學/營養學院/保健營養學研究所/碩士(2020年)

摘要

Background: Anemia has been shown to be global health problem with several significant adverse health outcomes. Recent evidence found that being active smoker, having sleep disturbance, higher alcohol consumption, poor dietary intake and nutritional status contributes in higher prevalence of anemia.
Aims: This study aimed to investigate the association between dietary pattern, nutritional status, lifestyle, and anemia related biomarkers among adult population. Specifically, this study would like to observe the association between: (1) Dietary patterns that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (2) Nutritional status that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (3) Lifestyle that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (4) Other biochemical variables (e.g. white blood cells and c-reactive protein) that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults.
Methods: The total of 43.055 men and 75.869 women acquired from health screening institution, Mei Jau (MJ) Health Management Institution, Taiwan from 2001 to 2015. The self-reported questionnaire included demographic, lifestyle, medical history, and dietary habit using semi-quantitative food frequency questionnaire (SQ-FFQ) will be retrieved from MJ database. Anthropometric and biochemical data of study participant also obtained from the same database. Statistical analysis will be performed to clarify the association between dietary pattern, nutritional status, lifestyle, and anemia related biomarkers among adult population in Taiwan.
Results: RRR-derived anemia dietary pattern significantly reduced anemia incidence and specifically decreased the amount of hemoglobin, hematocrit, and red blood cells, while increased the level of white blood cells and c-reactive protein. Furthermore, compared to normal weight status, being underweight (OR= 1.20, 95% CI 1.10, 1.42), having excess weight status (OR= 1.23, 95% CI 1.10-1.38 for overweight and OR= 1.34, 95% CI 1.22,1.48 for obese) and central obesity (OR= 1.28, 95% CI 1.18, 1.39) positively associated with anemia incidence. Interestingly, participants who were actively smoking or used to be smoking was inversely associated with anemia (OR= 0.68, 95% CI 0.63, 0.74 and OR= 0.74, 95% CI 0.64, 0.86, respectively). Current alcohol drinker was more likely to have higher incidence of anemia by 46% (OR= 1.46, 95% CI 1.32, 1.61).
Conclusion: Higher dietary scores of eggs, meats, organ meats, rice or flour products, fried food, sugary beverages, and processed food, is observed to increase the number of anemia prevalence in general. Moreover, anemia incidence is associated with anthropometric and lifestyle variables, such as smoking and alcohol drinking.

關鍵字

貧血 ； 成人 ； 飲食模式 ； 人體測量學狀態 ； 生活方式

並列摘要

Background: Anemia has been shown to be global health problem with several significant adverse health outcomes. Recent evidence found that being active smoker, having sleep disturbance, higher alcohol consumption, poor dietary intake and nutritional status contributes in higher prevalence of anemia.
Aims: This study aimed to investigate the association between dietary pattern, nutritional status, lifestyle, and anemia related biomarkers among adult population. Specifically, this study would like to observe the association between: (1) Dietary patterns that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (2) Nutritional status that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (3) Lifestyle that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults; (4) Other biochemical variables (e.g. white blood cells and c-reactive protein) that link to anemia related biomarkers (e.g. hemoglobin, hematocrit, and red blood cells) among adults.
Methods: The total of 43.055 men and 75.869 women acquired from health screening institution, Mei Jau (MJ) Health Management Institution, Taiwan from 2001 to 2015. The self-reported questionnaire included demographic, lifestyle, medical history, and dietary habit using semi-quantitative food frequency questionnaire (SQ-FFQ) will be retrieved from MJ database. Anthropometric and biochemical data of study participant also obtained from the same database. Statistical analysis will be performed to clarify the association between dietary pattern, nutritional status, lifestyle, and anemia related biomarkers among adult population in Taiwan.
Results: RRR-derived anemia dietary pattern significantly reduced anemia incidence and specifically decreased the amount of hemoglobin, hematocrit, and red blood cells, while increased the level of white blood cells and c-reactive protein. Furthermore, compared to normal weight status, being underweight (OR= 1.20, 95% CI 1.10, 1.42), having excess weight status (OR= 1.23, 95% CI 1.10-1.38 for overweight and OR= 1.34, 95% CI 1.22,1.48 for obese) and central obesity (OR= 1.28, 95% CI 1.18, 1.39) positively associated with anemia incidence. Interestingly, participants who were actively smoking or used to be smoking was inversely associated with anemia (OR= 0.68, 95% CI 0.63, 0.74 and OR= 0.74, 95% CI 0.64, 0.86, respectively). Current alcohol drinker was more likely to have higher incidence of anemia by 46% (OR= 1.46, 95% CI 1.32, 1.61).
Conclusion: Higher dietary scores of eggs, meats, organ meats, rice or flour products, fried food, sugary beverages, and processed food, is observed to increase the number of anemia prevalence in general. Moreover, anemia incidence is associated with anthropometric and lifestyle variables, such as smoking and alcohol drinking.

並列關鍵字

anemia ； adults ； dietary patterns ； anthropometric status ； lifestyle

參考文獻

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