生醫多孔性棉狀植體之顯微結構特徵與應力分析

奈米多孔性複合材(nanosprous composite)的原理來自於引導組織再生術的觀念，是藉由使用再生膜來阻隔上層軟組織，預防軟組織先長入欲重建之骨缺損區域，讓生長較慢的骨細胞可以遷移、增生，以達到骨再生成的目的，而這些痊癒的過程可由組織學上的研究發現得到印證-唯有牙周組織和牙根連接才是功能性牙周組織的再生，當牙周組織逐漸癒合時，能利用再生膜來隔絕生長速率較快的牙齦上皮細胞，並提供一個穩定的環境與生理性空間，讓生長較慢的細胞(牙骨質、牙周韌帶以及齒槽骨)保有其原有的生長區域以及其組織修復所需之時間。有鑑於此，用於引導組織再生術中的再生膜之孔洞、厚度、強度、使用材料的生物相容性等等物化性質便直接地影響引導組織再生術的最終結果。因此，如何精準地控制再生膜的孔洞、結構、物化性質等，便成為製造引導組織再生膜過程中一項重要的課題。本研究利用生物相容性極佳之複合材料做為再生膜的基材，並藉由力學性質分析、物化性質分析等驗證，以取得最佳化之再生膜條件，並可作為未來動物實驗以及臨床測試之有利依據。

關鍵字

奈米孔洞；組織再生；複合材

並列摘要

The principle of nanosprous composite from the concept of guided tissue regeneration (GTR), by using membrane to block the upper soft tissue, prevent the soft tissue first ingrowth to the bony defect area to be rebuilt, enable migration and proliferation of slower growth bone cell, in order to achieve the purpose of bone regeneration. The healing process can be confirmed by histological studies – regeneration of functional periodontium occurs only as the connection of periodontium to root surface. When periodontium gradually healed, the use of membrane isolated from the faster growth gingival epithelial cells that provide a stable environment and physical space for the slower growth cells (cementum, periodontal ligament, and alveolar bone) to retain its original growth area, as well as tissue repair time required. Pore size, thickness, strength of regeneration membrane, as well as its physical-chemical quality of material (biocompatibility) will affect the final outcomes of guided tissue regeneration directly. Therefore, it become a very important issue to find out a method for controlling the pore size, structure and physical-chemical quality of regeneration membrane. This study will utilize the composite as a substrate, and then by the mechanical properties, physical and chemical properties test, in order to obtain the optimized composite membrane. It can be a favorable basis for future animal experiments and clinical trials.