- 學位論文
烏腳病盛行地區居民缺血性心臟病與血清中微量營養素及砷甲基化代謝能 力之相關性研究
A Study on the Association of Ischemic Heart Disease with Serum Micronutrients and Arsenic Methylation Capability among Residents in Blackfoot Disease Hyperendemic Area
並列摘要
The objective of this study is to elucidate the association among ischemic heart disease,chronic arsenic exposure indices, serum micronutrients(vitaminA, vitamin E, lycopene, α-carotene, β-carotene), urinary arsenic species(AsIII,DMA, MMA and AsV) and other risk factors. 74 prevalence cases of ischemic heart disease and 193 age-sex-matched healthy controls were selected from a study cohort of residents lived in three villages where blackfoot disease was hyperendemic. Urinary arsenic species were isolated by high performance liquid chromatography.(HPLC) and determined by automic absorption spectrometry(AAS). Serum micronutrients were determined by Htomic absorption spectrometry. There was no significant difference between urinary arsenic species and ischemic heart disease except total arsenic level. A significant dose-response relationship was observed between ischemic heart disease and drinking high- arsenic artesian well water.The relation was boarderline significant after adjustment for age,sex,α-caroteneor β- carotene, total cholesterol level, body mass index(BMI) and hypertension. There was a negtive dose-response relationship between α-carotene or β-caroteneand ischemic heart diseas. The relation on β-carotene was also significant and α-carotene was boraderline significant after adjustment for age, sex, drinkinghigh-arsenic artesian well water, total cholesterol, BNI and hypertension. Otherrisk factors, except hypertention, such as serum triglyceride, cholesterol, high density lipoprotein, low density lipoprotein, apolipoprotein A1, apolipoprotein B concentration, smoking, alcohol drinking, and liver function indices, had no significant association with ischemic heart diseas.
被引用紀錄
延伸閱讀
- 林莉茹、洪申發、廖崑富、薛玉梅、邱弘毅、江明禧、戴東原、曾慶孝、陳建仁（1995）。烏腳病盛行地區缺血性心臟病之病例對照研究。中華公共衛生雜誌，14(6)，502-511。https://doi.org/10.6288/CJPH1995-14-06-07
- 陳惠雯（2002）。台灣烏腳病盛行地區高血壓與含錳超氧歧化酵素基因多形性之相關性研究〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714494824
- Chang, Y. L. (2021). 氧化壓力及非運鐵蛋白結合鐵在貓慢性腎臟病與病程進展之相關性 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU202103831
- 謝宜蓁、洪啟宗、王淵宏、陳建仁、邱弘毅（2005）。The Association between Carotid Atherosclerosis and Inflammatory Gene Polymorphisms Among Residents in an Arsenic-Endemic Area。台灣公共衛生雜誌，24(1)，64-72。https://doi.org/10.6288/TJPH2005-24-01-06
- 周怡利（2000）。A stduy on the association between carotid atherosclerosis and genetic polymorphisms of apolipoprotein E and lipoprotein lipase, inorganic arsenic methylation capability among various arsenic exposure people.〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714352608