臺灣民間常用生藥""旱蓮草""與""蒲公英""對各種肝毒性物質所誘發急性肝障害的保護作用之研究

Abstract ： Hepatoprotective effects of Ixeris chinensis（ Thunb.）Nak. and Eclipta prostrata（ Linn. ）were studied on acute hepatitis induced in mice by a single dose of carbon tetrachloride （ 31.25μl/kg ,ip ）or acetaminophen （ 600 mg/kg i.p. ）and in rats by a single dose of β-D- galactosamine （ 188mg/kg, ip ）． Hepatoprotective activity was monitored by estimating the serum transaminases（ SGOT and SGPT ） levels and histopathological changes in the liver of experimental animals．The Ixeris chinensis（ Thunb. ） Nak. extracts significantly inhibited the acute elevation of serum transaminases caused by the three kinds of hepatotoxins. Histopathologically， the crude I. chinensis extracts significantly ameliorated the three hepatotoxins-induced histopathological changes in the livers of experimental animals. The Eclipta prostrata extracts significantly inhibited the acute elevation of serum transaminases induced by carbon tetrachloride in mice and byβ-D-GalN in rats. However, in the experimental model of acetaminophen, Although an inhibiting tendency was noticed in the E. prostrata treated group, but no significance could be observed. Histopathologically, the crude E. prostrata extracts significantly ameliorated either carbon tetrachloride or GalN- induced histopathological changes in the livers of experimental animals but no significant improvement could be observed in acetaminophen induced liver damage. All serological and histopathological effects of Eclipta prostrata and Ixeris chinensis were compared with those of Bupleurum chinense DC., which has been reported previously as a treatment criteria of hepatitis．

關鍵字

"肝毒性物質；生藥；保肝作用；旱蓮草；蒲公英；急性肝障害；醫學；肝毒性物質；生藥；保肝作用"

並列摘要

無資料

並列關鍵字

"hepatotoxins ； liver ； hepatoprotective effects ； MEDICINE ； hepatotoxins ； liver ； hepatoprotective effects"

國際替代計量

臺灣民間常用生藥""旱蓮草""與""蒲公英""對各種肝毒性物質所誘發急性肝障害的保護作用之研究

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