肉毒桿菌神經毒素注射咬肌對大白鼠顱顏生長發育之影響

Effects on the craniofacial growth and development by injection of botulinum neurotoxin into the masseter muscle of rat

廖怡萱(Liao Yi-Hsuan)

指導教授 ： 蔡吉陽 ； 蔡志孟

臺北醫學大學/口腔學院/牙醫學系碩博士班/碩士(2005年)

摘要

本研究目的是藉由將肉毒桿菌神經毒素注射入大白鼠咬肌，使咬肌萎縮，來探討咬肌對顱顏型態及生長發育的影響。研究方法是選取13隻30天年齡大的Wistar雄性大白鼠，分為實驗組10隻，將肉毒桿菌神經毒素施打入大白鼠一側咬肌，另一側施打生理食鹽水；對照組3隻大白鼠不施打任何藥劑。而後將75天年齡大的大白鼠殺死，取下咬肌測量重量，及量測乾燥頭顱骨。結果發現實驗組大白鼠施打肉毒桿菌神經毒素側其咬肌重量較施打生理食鹽水側及對照組小，其顱顏骨型態在顴骨弓至下顎骨緣距離，冠狀突切跡最前端至下顎骨角狀突最下點距離，均小於生理食鹽水側距離，有統計上之差異。實驗結果證實咬肌萎縮後，確實會影響顱顏骨型態及生長發育。

關鍵字

肉毒桿菌神經毒素，咬肌，肌肉萎縮，顱顏骨骼，生長發育

並列摘要

This study was to evaluate the influence of masseter muscle on the craniofacial growth and development by using the botulinum neurotoxin to cause the masseter muscle atrophy. 10 male Wistar rats (experiment group,30 days old) were received botulinum toxin injection in one side of masseter muscle and normal saline in the other side;3 rats(control group) were no injection.The rats were sacrificed at 75 days of age. Muscle sections of the masseter muscle were weighted and the anthropometric measurements were made directly on rat dry skull . The results showed that the muscle weight of botulinum toxin injection side decreased. The craniofacial morphology of the botulinum toxin injection side were smaller in distances of zygomatic arch to mandibular lower border and ramus height (Cor-Gn) than that of the normal saline injection side. It demonstrated that atrophy of masseter muscle altered the craniofacial growth and development.

並列關鍵字

botulinum neurotoxin, masseter muscle, muscle atrophy, craniofacial bone, growth and development

參考文獻

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