探討北台灣空氣污染暴露與心血管疾病生化指標間的關係

Association Between Exposure to Air Pollution and Biomarkers of Cardiovascular Disease in Northern Taiwan

孟多裡(Mandroy Pangaribuan)

指導教授 ： 莊凱任

臺北醫學大學/公共衛生學院/公共衛生學系暨研究所/碩士(2017年)

摘要

無資料

關鍵字

空氣污染 ； 生物標記物 ； 心血管疾病

並列摘要

Introduction: Exposure to air pollution has been associated with increased cardiovascular disease (CVD). The association was linked by a mechanism of biological of oxidative stress and systemic inflammation. Heart rate, Systolic Blood Pressure (SBP), Diastolic blood pressure (DBP), leukocyte, erythrocyte, hematocrit, and hemoglobin are some biomarkers of oxidative stress and systemic inflammation related to cardiovascular disease. However, to date, study about effects of air pollution on biomarkers of CVD in specific group in urban area remains very limited. This study was conducted to measure the association between ambient air pollution with biomarkers of CVD in adult people in the urban area of northern Taiwan.
Methods: This study was conducted by using a cross-sectional design. Data of biomarkers were extracted from the daily hospital admissions of pulmonary department of Shuang Ho Hospital in New Taipei City from 2014 – 2015. The daily concentrations for the air pollution namely24-h mean concentrations in µg/m3 and ppb for all pollutants except O3 for which the 8 hour maximum average, were averaged from the database of Taiwan Air Quality Monitoring Network. The data were analyzed using multiple linear regression. Lag up to 5 previous days was used in the analysis to measure the air pollution concentrations. Meteorological variables (temperature and relative humidity) and individual characteristics (sex, age, smoking status, and alcohol consumption) were included in the analysis. The beta coefficients and 95% CI were used to express the association. P-value < 0.05 was considered statistically significant.
Results: This study found statistically significant positive associations between air pollutants with heart rate, systolic blood pressure, and erythrocyte concentrations and statistically significant negative associations between air pollutants with hematocrit concentrations. On the other hand, this study found no significant association between air pollutants with diastolic blood pressure, leukocyte concentration, and hemoglobin concentration. For one unit increase of each air pollutant concentrations, the heart rate increased from 0.391 to 3.354 time/ minute. For one unit increase of air pollutant concentration, the SBP increased 1.359 mm/ Hg. For one unit increase of each air pollutant concentrations, the erythrocyte concentration increase from 0.327 106/ µL to 0.596 106/ µL. For one unit increase of each air pollutant concentrations, the hematocrit concentration decreased from 3.960 % to 7.999 %.
Conclusion: Short-term exposure to air pollution was associated with changes of some biomarkers of cardiovascular disease. This study observed statistically significant positive associations between air pollutants with heart rate, systolic blood pressure, and erythrocyte concentration and statistically significant negative association between air pollutants with hematocrit concentrations. On the other hand, this study found no significant association between air pollutants with diastolic blood pressure, leukocyte concentration, and hemoglobin concentration.

並列關鍵字

air pollution ； biomarkers ； cardiovascular diseases

參考文獻

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