靈芝蛋白8 (LZ-8)對小鼠皮膚傷口癒合之評估：調節嗜中性白血球、角質細胞和纖維母細胞

The benefit of LZ-8 as immunomodulatory protein has been widely studied. LZ-8 reported might accelerate rat liver wound injury. However, the effect of LZ-8 on skin wound healing is less studied.This study aimed to evaluate the effectsof LZ-8 in mouse skin wound healing and determine the molecular mechanism of LZ-8-induced acceleration of wound healing.Different group of wound were generated at C57Bl/6 mice dorsal skin followed by wound histology observation. To evaluate the effect of LZ-8 for fibroblast and keratinocyte migration we performed In Vitro wound healing assay.Our studied revealed that an increase in PMN infiltrations and collagen depositions in the wound of animals treated with LZ-8 on day 2 and day 3 respectively. In addition,we found that both fibroblast and keratinocyte migration were significantly increase under treatment with LZ-8In Vitro study of wound healing. These results suggested that LZ-8 not only modulate PMN cell infiltration, but also play an active role in enhancing fibroblast and keratinocyte migration and increase collagen deposition.

並列關鍵字

Keratinocyte ； Wound healing ； PMN cell infiltration ； Collagen ； Fibroblasts

參考文獻

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延伸閱讀

蘇暄（2012）。靈芝免疫調節蛋白 Ling Zhi-8 活化小鼠骨髓衍生性樹突細胞及刺激免疫細胞產生介白素-17A 之探討〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2012.10647
Yeh, C. H. (2010). 靈芝蛋白Ling Zhi-8鍵結於奈米金粒子促進巨噬細胞及脾細胞免疫調節能力與其粒徑依賴性質之探討 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2010.10777
蔣友邦（2012）。小孢子靈芝免疫調節蛋白質GMI雙體化對其免疫調節功能之影響〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2012.02604
Cheng, S. X. (2022). Investigation on HSV-1-induced activation and differentiation of dendritic cells in the skin of ENU-mutagenized alternatively-spliced IL-15 expressing mice [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU202203811
Trotter, A., Kipp, M., Schrader, R. M., & Beyer, C. (2009). Combined Application of 17β-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice. International Journal of Pediatrics, 2009(), 4-11. https://doi.org/10.1155/2009/170491

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靈芝蛋白8 (LZ-8)對小鼠皮膚傷口癒合之評估：調節嗜中性白血球、角質細胞和纖維母細胞

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