- 學位論文
專利分析-探討抗癌植物藥之現況與發展
Patent Analysis of the Current Situation and Development of Anti-cancer Botanical Drugs
摘要
癌症為全球主要死亡原因之一，每年新增約1,000多萬人罹患癌症。隨著全球各國罹癌人口的增加，癌症新藥開發為各國生技製藥產業的重要一環。在許多已開發國家，由於對化學藥品引起副作用之疑慮以及有關健康教育資訊大量公開，以個人生理狀況為依據給予治療的傳統醫學療法逐漸受到重視。而傳統醫學也被認為可以治癒現代醫學無法治癒之疾病，如一些慢性病症等。據統計全球有四分之三以上的人口曾經嘗試使用草藥或中藥治療疾病，對於中草藥之研究也越來越受重視，促使生技製藥業愈投入在植物藥開發。 本文將透過專利檢索搜尋現有抗癌植物藥已核准專利以及早期公開之專利申請以了解抗癌植物藥專利申請現況，對檢索得到專利文件進行整理後，利用專利分析方法對專利文件做質性及量性分析，並將利用統計方法探討國家別、抗癌植物藥之專利申請其作用路徑等是否具有顯著差異，以及探討抗癌植物藥的研究發展趨勢。 本研究結果發現抗癌植物藥專利申請之分佈在美國、澳大利亞、歐洲、日本、加拿大以及中國居多，但在2009年之後其發展有衰退趨勢。另外所使用之抗癌植物藥以複方為主，且主要機制為直接毒殺癌細胞及影響癌細胞生長。
並列摘要
Nowadays, cancer has become one of the main causes of death around the world. Each year, more than 10,000,000 new patients suffer from cancer around the world. As the increase of cancer population, the development of anti-cancer drug research becomes an important part of the biotech pharmaceutical industry. Because of the doubt of the side-effect from chemical medicine and more contacting from the information of health education, people around the world tend to accept traditional medical care which can give personal treatment to patients. In addition, traditional Chinese medicine is believed to cure some chronic disease. As a result, more and more biotechnology industry put in botanical drug research. This research is to find patents about anti-cancer botanical drug and to understand the current situation of its patent applications, organize and classify of these patent files in order to do quantitative and qualitative analysis. This research will also explore the significance between different country and the significant between country and pharmaceutical pathway using statistics analysis. This research will also confer the research development of anti-cancer botanical drug. The results show that anti-cancer botanical drug therapy is widely distributed in the U.S., Australia, Europe, Japan, Canada and China. The development of anti-cancer botanical drug patent application shows a decline after 2009. In addition, most anti-cancer botanical drug patent applications are compound preparation and the main mechanism has direct effect of cancer cell apoptosis and growth.