The Core pattern design is the most important mission of nuclear power plant. Simulated Annealing, genetic algorithm, Tabu search and expert system type solutions apply on this task, decreasing mass neutronics dynamics computation. Genetic programming is a new information technology. Through the verifying of core follow evolution, validates GP can handle it all. Not only excellent presentation, the limitless potential can help more efficient in hi-tech researching. This achievement is a pioneer on the fuel layout application.