In this study we examine the profitability of medium-term global momentum strategies as twenty developed markets are considered. Empirical results indicate significant global momentum profits and those profits are still persistent when the country factor, the regional factor and the industry factor have been controlled for. Significant momentum profits are extensively observed for individual markets and regional economies around the world, with the exceptions of Spain, Finland, and the Pacific Rim countries. Among them, we find that momentum profits decrease with firm size and become less profitable once we control for the size, the growth factor or the industry. Consistent with earlier studies, the momentum returns in all cases become negative in January while maintain positive returns in all other months. Last, the momentum profits adjusted for the Fama-French three factors still exhibit significantly positive returns, indicating the persistence of this market anomaly.