The detailed layout is the extension of the block layout and it considers more factors than block layout such as limited available areas, aisles, exit/entrance, orientation, clearance, etc. In this study, the qualitative matrix is obtained by the Max-Δcomposition of the fuzzy sets theory, then the flow matrix is normalized to get the quantitative matrix. The weighted matrix is obtained by the weight of qualitative and quantitative matrix. A multi-rows machine layout model is modified to this detailed layout model. A heuristic approach is developed by genetic algorithm (GA) so that an acceptable solution can be obtained without being trapped in local optimum. An example of a operation room of a local hospital was illustrated. Finally, the Taguchi method is conducted to find the best combination of GA parameters. When compared with the traditional SLP method, the results show that this approach can obtain a better solution.