A unified, three-dimensional, steady-state numerical mass-transfer sing cell model for proton exchange membrane fuel cell (PEMFC) was developed. This model can predict the phenomenon in the fuel cell, and difference channel pattern influence the cell performance. The flow channel pattern play an important role in fuel cell design. The fuel cell performance will be directly affected by the flow channel pattern. In other word, the proper flow channel design will help the fuel cell to get rid of the producing water and heat. The purpose of this study is to numerically simulate the mass transfer of gas in flow channel with different pattern (straight flow, and serpentine flow) and investigate the change of the pressure, flow rate, pressure drop. We found that the flow characteristic in serpentine flow pattern is much better than that in straight flow pattern meaning that the application of serpentine flow pattern in proton exchange membrane fuel cell is much feasible to let the character of MEA come out completely.