Since 2002, Taiwan has adopted total amount payment system for hospitals. This has increased the conflicts between payers (government) and the healthcare providers. To control for the high costs of providing healthcare, many hospitals have resorted to cost-based management system. Prior studies indicate that clinical service generates higher gross margin than hospitalization and the higher the level of the hospitals, the higher percentage of surgical hospitalization. Thus, for high-level hospitals such as teaching hospitals, establishing the activity-based cost management system has become more urgent. This system provides a clear link between resources spent and activities performed for the managing the cost drivers. This study find that (1) the multi-level cost attribution models can assist the case hospital to determine the profit/loss of individual operations; (2) using individual patients as the cost object to determine the cost difference of similar operations; (3) the cost attribution can be used to evaluate physicians’ performance and the operation room capacity utilization rate; and (4) whether the reimbursements by the payer are sufficient to cover the total costs and also an be used as the basis for negotiating with the payer.