人類轉錄因子交互作用之研究與辨識

Investigation and Identification of Transcription Factor Interactions in Human

謝宜俽(Yi-Shin Hsieh)

指導教授 ： 李宗夷

元智大學/資訊學院/生物與醫學資訊碩士學位學程/碩士(2013年)

https://doi.org/10.6838/YZU.2013.00250

摘要

蛋白質交互作用(protein-protein interaction)廣泛參與了生物化學、量子化學、分子動力學、訊息傳遞等代謝或遺傳學。人類的生化功能亦是會依靠蛋白質間的交互作用。蛋白質的生產是由轉錄這個機制所調控的，因而此機制在生化過程中，扮演著重要角色。調控轉錄過程的蛋白質被稱為轉錄調控因子(TF)，此蛋白質發揮其功用亦是與其他蛋白質發生交互作用，進而達成其作用目標。目前以生物技術的方法來分析人類轉錄因子的交互作用性，將會是一件費時間與金錢的工作；因此，我們預期能提供生物學家一個有用的計算分析方法，藉由電腦計算達到減輕生物學家人力與時間金錢上的耗費，為人類轉錄因子交互作用研究上能更快速發展。在本篇研究中，藉由參考前人研究與辨識protein-protein interactions 的方法，運用上人類轉錄因子交互作用(human transcription factor interactions )進行分析，預期能達到高效能的辨識。

關鍵字

人類轉錄因子交互作用 ； 轉錄因子交互作用 ； 轉錄因子

並列摘要

Protein interactions are extensively involved in biochemistry, quantum chemistry, molecular dynamics, messaging and other metabolic or genetic. Human biochemical function will also depend on protein-protein interactions. Protein production is regulated by the transcription of this mechanism, and therefore this mechanism in biochemical processes, plays an important role. Transcription regulating proteins called transcription factor , this protein functions play its interaction with other proteins, thereby to achieve its objective function. Currently biotechnology methods to analyze the interaction of the human transcription factor, it will be a time-consuming work and money; therefore, we expect to provide biologists a useful computational analysis methods, achieved by computing reduce biologists manpower and time-consuming for the study of the human transcription factor interactions can be more rapid development. In this study, by referring to previous studies and identification of protein-protein interactions of the method, the use of the human transcription factor interactions were analyzed, it is expected to achieve high performance identification.

並列關鍵字

transcription factor interactions in human ； transcription factor interactions ； transcription factor

參考文獻

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