A novel CMOS image sensor with log-lin-log response is presented. The pixel cell has logarithmic response in very low illumination intensity, linear response in low and medium illumination intensity, and logarithmic response in high illumination. In this scheme, the sensor is highly sensitive to very low light, while still owning the properties of high voltage swing of 0.53V (from 1.8V supply) and high dynamic range of 120dB. Furthermore, CDS technique can be applied to the proposed sensor array to reduce the fixed pattern noise. For the purpose of demonstration, a prototyped image sensor array of 75x54 with readout circuit and CDS is designed and realized from 1.8V supply in the TSMC 0.35µm CMOS 2P4M standard process.