利用PEG-400進行Imidazo[2,1- a]isoquinolines與置換Quinolines的合成研究

An Efficient Synthesis of Imidazo[2,1-a]isoquinolines and Substituted Quinolines in Liquid PEG-400

杜皓東(Hau-Dung Du)

指導教授 ： 陳麟慶

高雄醫學大學/藥學院/藥學研究所/碩士(2010年)

https://doi.org/10.6832/KMU.2010.00010

摘要

高價碘(III)化合物由於是一種低毒性、方便使用、容易處理的反應試劑而廣泛被使用。其中以 [hydroxyl(tosyloxy)iodo]benzene(HTIB) 、phenyliodine(III) diacetate (PIDA) phenyliodine(III) bis(trifluoroacetate) (PIFA)等最常被使用在合成化學。
聚乙二醇(polyethylene glycol; PEG) 眾所皆知是價格便宜、可回收、無毒、具熱穩定性和生物相容性的聚合物；聚乙二醇於各種的有機轉化中，最常被當作支持物或是相轉移的觸媒，與典型的分子性溶媒相較，聚乙二醇是更環保有效的反應媒介。
本研究計劃利用催化合成的高價碘 (III) 試劑在 PEG-400 中進行imidazo[1,2-a]isoquinolines 及置換quinolines 衍生物的合成研究。

關鍵字

聚乙二醇-400 ； 咪唑[2,1-α]異喹啉置換-喹啉

並列摘要

Hypervalent iodine(III) compounds have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handling. [Hydroxyl(tosyloxy)iodo]benzene (HTIB), phenyliodine(III)
diacetate (PIDA) and phenyliodine(III) bis(trifluoroacetate) (PIFA) are the most frequently used and easily available reagents in the family of iodine compounds.
Polyethylene glycols (PEG) are well-known to be inexpensive, recoverable, non-toxic, thermally stable, and biological compatible polymers. Polyethylene glycols are most commonly employed as a support or a phase-transfer catalyst in various organic transformations.
Compared with classical molecular solvents, the polyethylene glycols are
environmentally benign reaction media.
In this work, catalytic reaction of hypervalent iodine(III) reagents and PEG-400 will be applied to prepare imidazo[2,1-a]isoquinolines and substituted quinolines.

並列關鍵字

PEG-400 ； Imidazo[2,1-a]isoquinolines ； Substituted Quinolines

參考文獻

參考文獻

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(b) Ahn, J. M.; Wentworth Jr, P.; Janda, K.D. Chem. Commun., 2003, 480.

2. Harris, J. M. “Poly(ethylene glycol) chemistry biotechnical and

biomedical applications”, New York Plenum Press 1992, 1.