2-取代之3-苯基喹啉類衍生物的合成以及抗增生活性評估

Synthesis and Antiproliferative Evaluation of 2-Substituted 3-Phenylquinoline Derivatives

林科佑(Ke-You Lin)

指導教授 ： 曾誠齊

共同指導教授 ： 陳義龍(Yeh-Long Chen)

高雄醫學大學/生命科學院/醫藥暨應用化學研究所/碩士(2012年)

摘要

本研究主要探討3-苯基喹啉衍生物的合成和其抗增生活性的評估。合成方面，3-苯基喹啉衍生物主要是在C-2上以縮氨硫脲基團和肟基團做取代。抗增生活性方面，主要用人類乳癌細胞株(MB-321)進行抑制腫瘤細胞生長活性測試。
研究結果指出在C-2上以肟基團取代時，並沒有抑制活性。以N,N-二甲基縮氨硫脲基(化合物18a-f)取代時，有明顯較好的抑制活性。

關鍵字

喹啉

並列摘要

This thesis describes the synthesis and antiproliferative evaluation of 3-phenylquinoline derivatives. The substituted groups of these newly synthesized compounds are thiosemicarbazons group and oxime group. These compounds were evaluated for their antiproliferative activities against breast cancer cell line (MB-231).
Result of this study indicated that the substituted groups are oxime groups showed no antiproliferation activities. The derivatives of thiosemicarbazones bearing dimethyl group (18a-f) showed promising antiproliferative activity.

並列關鍵字

quinoline

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