分化型甲狀腺癌患者接受高劑量原子碘治療體內劑量評估及輻射防護病房汙染管控

Internal dosimetry dose assessment and I-131 ward radiation contamination survey in DTC patients with high dose radioiodine therapy

鍾玫棽(Mei-Ling Chung)

指導教授 ： 賴永昌

高雄醫學大學/健康科學院/公共衛生學系職業安全衛生碩士班/碩士(2017年)

摘要

本研究分作兩個部分，分別為體內劑量研究及環境輻射汙染研究。
體內劑量研究以服用高劑量分化型甲狀腺病患作為高劑量輻射暴露
族群，體內劑量以服用 100mCi 為 0.92±0.29 Sv，而服用 200mCi 的體內劑量則為 1.97±0.76 Sv，將 100mCi 及 200mCi 病患之體內劑量進行T-test，得到 p-value > 0.05 無顯著，證實投予劑量和服藥後輻射藥物劑量滯留呈正比相關性；環境輻射暴露研究以輻射防護病房進行環境輻射暴露研究，做為模擬輻射暴露居家環境的情形，發現病患以肢端接觸的地方如冰箱門把、電視遙控器及廁所門把等肢端接觸等處將有
較高的輻射汙染量。另外，靠近空調的衣櫃之頂板上的灰塵因空氣流
動使得上面附著較高的輻射量。

關鍵字

分化型甲狀腺癌 ； 高劑量原子碘治療 ； 遠距輻射測量系統 ； 醫療體內輻射劑量 ； 環境輻射汙染

並列摘要

This research is divided into "Internal dosimetry" and "Environment dose". For the first part, Differentiated Thyroid Cancer (DTC) patients who took radioiodine 100mCi would get the internal dose 0.92±0.29 Sv Sv, those who took 200mCi would get the internal dose 1.97±0.76 Sv. It’s statistically non-significant for the internal dosimetry, same as clinical result and it proofs the dose gave from doctor and radiation dose after drug retention are positive correlations; Second part, Environmental Radiation Contamination in the radiation protectoral therapy, in all tests, "Fridge doorknob", "Remote control" and "Bathroom doorknob" those touch by hands are top 3 dirty spots, the highest is "Fridge doorknob", it
can be 1187.8 Bq. The other hypothesis is dust could catch the organic iodine by patient expiration May or the other types of Iodine-131 after human metabolism.

並列關鍵字

Differentiated Thyroid Cancer ； Radio Ablation Iodine ； Remote-Measurement system ； Medical Internal Radiation Dose ； Environmental Radiation Contamination

參考文獻

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