高價碘試劑由於是一種低毒性、易處理的反應試劑而廣泛被使用。其中的phenyliodine(III) diacetate (PIDA)、phenyliodine(III) bis(trifluoroacetate) (PIFA)及[hydroxyl(tosyloxy)iodo]benzene (HTIB)是最常被使用的高價碘化合物。 Room temperature ionic liquids(RTIL) 室溫離子溶媒是完全由離子組成的液體。事實上, 離子溶媒可以在室溫或室溫以下(甚至低到-90℃)保持液體,容易製造且花費不貴。離子溶媒因為易於回收、不易燃、具有不揮發的性質,跟典型的分子性溶媒相較,離子溶媒是更環保有效的反應媒介。本研究計劃利用高價碘(III)試劑在離子溶媒中進行雜環的合成研究。
Hypervalent iodine reagents have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handing. Phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA) and [hydroxyl(tosyloxy)iodo]benzene (HTIB) are the most frequently used and easily available reagents in the family of iodine compounds. Room temperature ionic liquids (RTIL) are liquids that are composed entirely of ions. In fact, ionic liquids can now be produced which remain liquid at room temperature and below (even as low as -90℃) and appear to be undemanding and inexpensive to manufacture. Ionic liquids offer an attractive alterative to conventional organic liquids for clean synthesis, as they are easy to recycle, lack flammability, and possess effectively no vapour pressure. Compared with classical molecular solvents, the ionic liquids are environmentally benign reaction media. In this work, hypervalent iodine(III) reagents will be applied to prepare heterocycles in ionic liquids.