Diarylalkynes在水中經由鈀催化劑與三氧化鉻氧化反應下得到1,2-diaryldiketones

Pd-catalyzed oxidation of diarylalkynes into 1,2-diaryldiketones with CrO3 in water

王貫倫(Guan-Lun Wang)

指導教授 ： 王英基

高雄醫學大學/生命科學院/醫藥暨應用化學系碩士班/碩士(2015年)

摘要

本研究中，由各類苯甲醛化合物經由三個合成步驟得到diarylalkynes，再經由PdCl2/CrO3/H2O進行氧化反應，發現到在多個甲氧基取代的diarylalkynes，經由此氧化系統可得到相對高產率的diaryldiketones，然而較少或是沒有取代的diarylalkynes會得到較低產率甚至是微量的diaryldiketones。

關鍵字

三氧化鉻 ； 鈀金屬催化 ； 水

並列摘要

In this study, the oxidation of diarylalkynes, which were prepared from benzaldehyde through three synthetic steps, with PdCl2/CrO3/H2O was described. We found the multiple-methoxy substituted diarylalkynes can be oxidized by the oxidation system to give corresponding diaryldike
-tones (benzyls) in excellent yields. However the less or no substituted diarylalkynes gave diaryldiketones in low yield or in trace amount.

並列關鍵字

CrO3 ； Pd-catalyzed ； H2O

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