慢性鉛暴露對腦部磁振頻譜的研究

Effect of Chronic Lead-exposure on Brain Magnetic Resonance Spectroscopy

陳怡君(Yi-Chun Chen)

指導教授 ： 莊弘毅

共同指導教授 ： 賴永昌(Yung-Chang Lai)

高雄醫學大學/健康科學院/職業安全衛生研究所/碩士(2007年)

摘要

無資料

關鍵字

鉛 ； 腦中代謝 ； 磁振頻譜 ； K軌域X射線螢光繞射

並列摘要

Background: Lead had been known as a human health hazard for a long time. In particular, damages to brain and nervous system are the main issue in the lead toxicites. The goal of this study is to investigate the brain metabolism using a 3 T magnetic resonance spectroscopy (MRS) in a group of chronic lead-exposed workers in comparison with the matched non-exposed control group.
Materials and Methods: The lead-exposed subjects were from a lead paint manufactory, total of 22 workers is included. They did not show any clinical syndromes. Eighteen age and sex matched non-exposed healthy people as control group were voluntarily participated. Blood samples were send to KMU hospital for blood lead concentrations and other biochemistry tests. Bone lead levels were measured by a KXRF equipment. A 3T MRS was used to measure their brain N-acetyl aspartate (NAA), Choline (Cho), and creatine (Cr) levels. In addition, a structural questionnaire was used to collect their working and health histories, as well as smoking, alcohol consumptions.
Results: In comparisons of NAA/Cr, the frontal gray, subcortical, and white matters of Lead-exposed group had significantly lower NAA/Cr ratio, comparing to the non-exposed group. In the occipital lobe, only NAA/Cr ratio of white matter in the lead-exposed group was significant lower than those of non-exposed group. The NAA/Cr ratio of basal ganglions were also lower in the exposed group than those of non-exposed group. Similarly, in comparison of Cho/Cr ratio, the data of frontal gray, white matters in exposed group were lower than those of non-exposed. In occipital lobe, all the gray, subcortical, and white matters in the exposed group had lower Cho/Cr ratio than those of non-exposed ones.
Discussion: The lead toxicity to human brain is complex, and not well recognized. However, this study found that brain metabolism, especially NAA/Cr and Cho/Cr, may be disturbed by lead. Brain NAA and choline were negative correlated to blood and bone lead levels, which may mean that lead may induce a neuronal and axonal damage or loss.

並列關鍵字

lead ； brain metabolism ； MRS ； bone lead KXRF

參考文獻

REFERENCE

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