新法合成2H-苯駢哌喃衍生物

A new method for the synthesis of chromene derivatives

李達方(Da-Fang Li)

指導教授 ： 王英基

高雄醫學大學/生命科學院/醫藥暨應用化學研究所碩士在職專班/碩士(2008年)

摘要

本研究以Resorcinol作為起始物質，藉由烷基化反應、Wittig反、RCM反應和克萊森轉位，成功開發2H-chromenes衍生物之新的合成法，並以osthol結構的類似骨架為最後目標。此合成法中，將resorcinol分別與acetyl chloride、benzyl bromide、allyl bromide、Wittig試劑反應，並利用第二代Grubbs’催化試劑進行RCM反應，最後以克萊森轉位，合成出類似osthol結構之2H-chromenes化合物。

關鍵字

苯駢哌喃衍生物

並列摘要

A new route to the synthesis of chromene derivatives from resorcinol is studied.The synthetic rout involues Wittg reaction, alkylation, ring-closing metathesis (RCM) and Claisen rearrangement. The final products have the similar skeleton to osthol structure. In the new synthetic approach, the chromene derivatives prepare from the resorcinol that was reacted with acetyl chloride, benzyl bromide, allyl bromide and methoxyacetophenone. Then, the diene compounds were reacted with Grubb’2nd catalyst via ring-closing metathesis (RCM).

並列關鍵字

chromene derivatives

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