注射劑藥品在多種大型輸注容器中吸附之研究

Sorption of injectable drugs in various types of large volume parenteral containers

鍾易憲(I-Hsien Chung)

指導教授 ： 詹道明

高雄醫學大學/藥學院/藥學研究所/碩士(2004年)

摘要

選擇Epinephrine HCl、Chlorpromazine HCl、Lorazepam、Diazepam以及Isosorbide dinitrate等5種醫院診所常用之注射劑藥品，探討它們於四種不同材質【glass，polypropylene（PP），, polyethylene multilayer（ML）及polyvinyl chloride（PVC）】之大型輸注液中的安定性。所謂安定性便是指(1) 藥品在混合溶液中濃度之經時變化，(2) 混合溶液pH值之經時變化。文中分別利用高效能液相層析儀 ( high performance liquid chromatograph，簡稱HPLC ) 及pH meter來分析測定上述5種藥品於大型輸注液容器中，經24小時後，除Isosorbide dinitrate於PVC大型輸注液容器中，經24小時後，藥品濃度比原來之濃度減少25 %左右及diazepam於PVC容器中減少約70 %外。Epinephrine HCl、Chlorpromazine HCl及Lorazepam之濃度於四種材質之容器中，並無太大的改變。而由pH值的實驗結果得知，這6種藥品於4種不同材質容器的大型輸注液中的pH值，經24小時之後，並無太大的改變。藥品的濃度與儲存溫度也會對吸附的量造成影響，兩藥品分別注入PVC中，注入的藥品濃度愈高，被吸附的量也提高，在儲存的環境方面，儲存於4 ℃ PVC軟袋中藥品被吸附的量小於存放於室溫中的PVC軟袋。

關鍵字

吸附 ； 注射劑 ； 高效液相層析儀 ； 大型輸注液 ； Epinephrine HCl ； Chlorpromazine HCl ； Lorazepam ； Diazepam ； Isosorbide dinitrate

並列摘要

The aim of this study was to estimate the stability of six drugs (Isosorbide dinitrate, Epinephrine HCl, Chlorpromazine HCl, Lorazepam and Diazepam) that they usually used in clinic and hospital. Firstly, it was injected into 250 ml, four kinds of large volume parenteral containers (polyvinyl chloride (PVC) bags, glass bottles, polypropylene (PP) bottles, polyrthylene multilayer (ML) bags), respectively. Then, the high- performance liquid chromatography (HPLC) was used to quantitative analysis of drugs through 24 hours in the containers. The potency of Isosorbide dinitrate remained unchanged in glass, PP bottles and ML bags. In the PVC bags, about 25 ％ was lost during 24 hours in both glucose and normal saline solutions. Diazepam lossed about 70 ％. There was no appreciable changed in pH in four kinds of containers through 24 hours. In the concentration of drugs and stored temperature study, drugs dosage was injection into the PVC containers, the amounts of high-dosage group was sorption more than low-dosage group in PVC containers. In the same dosage of two drugs, the amounts of drug of sorption by PVC were decreased at 4 ℃.

並列關鍵字

HPLC ； injectable drugs ； sorption ； large volume parenteral ； Chlorpromazine HCl ； Epinephrine HCl ； Lorazepam ； Diazepam ； Isosorbide dinitrate

參考文獻

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