2-benzothiazoles的結構無論在醫藥方面或是光學材料方面都引起了相當大的注意。在醫藥方面相關的結構衍生物已經證實了對於癌細胞特別是乳癌細胞、卵巢癌細胞、結腸癌細胞、腎臟癌細胞都有非常好的選擇性及抑制作用,但是至今為止對於其如何抑制癌細胞的生長的機制卻還未明確的定義。但是初步的結果卻可以顯示這類型的藥物大多是與細胞的新陳代謝作用有關。本論文其中之一的目的就是合成以2-benzothiazoles為主體的抗癌藥物並且利用不同官能基的改變以進一步瞭解這類藥物的抗癌機制。 除了在抗癌研究上的目的之外,這類型的結構也是光學材料的熱門研究主題。利用改變不同組合的電子施體以及電子受體,期望可以得到更具商業價值的二次非線性光學材料。此外在發色團基中導入具有提高溶解度的功能三氟甲基不僅可以提高對於材料加工上的便利性,也是設計發光團基的上的一個嶄新的嘗試。
2-Benzothiazoles reported that they display potent and selective anti-tumor activity against inter alia breast, ovarian, colon, and renal cell lines, but their mechanism of action, through yet to be defined, may be novel. Metabolism is suspected to play a central role in the mode of action cell lines. We designed and synthesized different subtituents at aromatic positions of 2-benzothiazolesfor biological test. Beside the anti-tumor agents, the similar structures are also the novel start in the optical materials. More than change the different electron donor and accepter, we use the tri-fluoromethyl in the chromophores as the electron accepter, and the amine or hydroxyl group as the electron donor, the tri-fluoromethyl group not only be a electron accepter but also improve is solubility. The new idea maybe can solve the problem of low solubility.