從水楊醛（salicylaldehyde）經由ＲＣＭ新法合成3-取代的2H-Chromenes

A New Synthesis of 3-Substituted 2H-Chromenes from Salicylaldehydes via RCM

陳秋如(Chiu-Ju Chen)

指導教授 ： 王英基

高雄醫學大學/生命科學院/醫藥暨應用化學研究所/碩士(2005年)

摘要

本研究以水楊醛( salicylaldehyde )作為起始物質，藉由Wittig 反應，烷基化反應和RCM合環反應，開發出在3位置取代之2H-chromenes化合物之新法合成。在此新合成法中，將水楊醛分別與chloroacetone, 2-bromoacetophenone and 2-bromo-4’-methoxyacetophenone反應，所得之vinylbenzene化合物利用Grubbs’二代催化劑，以無水二氯甲烷作為溶媒，進行RCM合環反應，合成出在3位置取代之2H-chromenes化合物。

關鍵字

閉環置換反應合成法 ； 水楊醛

並列摘要

A new route to synthesis of 3-substituted 2H-chromenes from salicylaldehyde based on Wittig reaction, alkylation and ring-closing metathesis ( RCM ) is described. In the new synthetic way, the 3-substituted 2H-chromenes were respectively prepared from the salicylaldehyde through a sequent reactions that was reacted with chloroacetone, 2-bromoacetophenone and 2-bromo-4’-methoxyacetophenone. Then, the vinylbenzene compounds reacted with the Grubbs’ 2nd catalyst in dichloromethane via ring-closing metathesis ( RCM ) to give the desired compounds.

並列關鍵字

RCM ； Salicylaldehyde ； 2H-Chromene

參考文獻

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