Deception is part of human interaction. Even though there is not a specific clue ties to deception, it is believed that certain verbal and nonverbal cues can be observed on liars due to heavy cognitive load needed for deception. In this study, 23 participants, age ranged from 21 to 29, were interviewed to collect a total of 498 truthful and deceptive responses, and then three facial cues were automatically constructed with a public facial landmark detection system for deception detection. The three cues included participants’ facial landmark distance change over neutral state, average facial landmark distance variation over frames and blinking frequency in a response. With a binary dependent variable as truthful and deceptive responses, logistic regression was used to study the relation between facial cues and deception. Result shows that tense behaviors as tightening lips and lower blinking frequency are significantly related to deception.