利用OLINDA/EXM及MCNPX進行錸-188微脂體藥物之診療患者體內劑量評估

Internal Dose Assessment of 188Re-Liposome Patient Estimated by OLINDA/EXM and MCNPX

梁貝儀(Leung, Pui Yee)

指導教授 ： 許榮鈞

國立清華大學/原子科學院/核子工程與科學研究所/碩士(2016年)

摘要

本研究應用MIRD Schema之體內劑量計算評估方法，利用蒙地卡羅方法及擬人數值假體模擬驗證放射性核種與源、靶器官之各組合所建立比吸收分率和S值，並使用OLINDA/EXM及MCNPX二程式，分別針對核研所研發之「錸-188微脂體」新型放射性奈米藥物之診療患者進行體內劑量評估，透過轉換小鼠實驗數據獲得人體體內分佈近似資訊，並採用擬人數值假體進行人體體內分佈模擬及接受單次診療時之全身有效劑量計算。

本研究設計二程式三方法進行體內劑量評估，所設計之OLINDA/EXM Method 1乃輸入具時間依存性之藥物分佈進行計算，而所設計之OLINDA/EXM Method 2及MCNPX二方法乃輸入注射藥物1小時之分佈並採用錸-188物理半衰期取代藥物半衰期進行計算。由OLINDA/EXM Method 1所得體內劑量評估結果，每給予1MBq之「錸-188微脂體」新型藥物於診療患者將造成約0.164mSv之全身有效劑量。而由本研究近似之OLINDA/EXM Method 2和MCNPX所得體內劑量評估結果，每給予1MBq之「錸-188微脂體」新型藥物於診療患者將造成分別約為0.197mSv及0.180mSv之有效劑量。由OLINDA/EXM Method 1與OLINDA/EXM Method 2、OLINDA/EXM Method 1與MCNPX及OLINDA/EXM Method 2與MCNPX按照排列組合進行結果比較及數據分析所得結果差異分別約為17.0%、9.6%、8.5%。

關鍵字

錸-188微脂體 ； 體內劑量評估 ； 蒙地卡羅方法 ； 放射性藥物

並列摘要

The MIRD Schema had been investigated in this study, as the specific absorbed fraction (SAF) and the S-values were calculated by Monte Carlo method and the results were found to be consistent with literature values. Then, OLINDA/EXM and MCNPX were used to undergo internal dose assessment of the patient of 188Re-BMEDA-liposome. Through converting experimental mouse model data into anthropomorphic data, the effective dose was estimated.

Three methods of dual programs have been designed for the internal dose evaluation; they were OLINDA/EXM Method 1, OLINDA/EXM Method 2 and MCNPX method. OLINDA/EXM Method 1 was designed with time dependent pharmaceutical distribution input while OLINDA/EXM Method 2 and MCNPX methods were designed with pharmaceutical distribution at 1 hour after injection, and also the effective half-life was replaced by physical half-life. The result obtained by OLINDA/EXM Method 1 was about 0.164mSv per 1MBq administered. The results obtained by OLINDA/EXM Method 2 and MCNPX method indicated that each patient would receive an effective dose of 0.197mSv per 1MBq administered and 0.180mSv per 1MBq administered respectively. After comparing the results obtained in combinations of OLINDA/EXM Method 1 vs. OLINDA/EXM Method 2, OLINDA/EXM Method 1 vs. MCNPX and OLINDA/EXM Method 2 vs. MCNPX, the differences of values were 17.0%, 9.6%, 8.5% respectively.

並列關鍵字

188Re-BMEDA-liposome ； Internal dose assessment ； Monte Carlo method ； Radiopharmaceuticals

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