含氮之5-6駢環雜環類抗癌化合物之合成和結構與活性關係(SAR)的研究

Synthesis and Structure-Activity Relationship of Nitrogen-Containing

董彥士(Yen-Shih Tung)

指導教授 ： 廖俊臣 ； 謝興邦

國立清華大學/理學院/化學系/博士(2007年)

摘要

本論文主旨在研究結構新穎之含氮之5-6駢環雜環類抗癌化合物之設計與合成，並進一步討論結構與活性的關係(structure-activity relationship，簡稱SAR)。研究方向分為二部份：第一部份係探討吲哚類之化合物之設計與合成及抗癌活性的研究；第二部份係探討非吲哚類(含氮5-6駢環雜環類)之化合物設計與合成及抗癌活性的研究。

關鍵字

含氮之5-6駢環雜環類 ； 抗癌化合物

並列摘要

This dissertation is focused on the design and synthesis of the fused 5-6 membered heterocyclic ring systems, containing either an indole or a non-indole moiety. A detailed study on structure-activity relationship (SAR) is outlined as follows.

並列關鍵字

Nitrogen-Containing Five - Six Fused Heterocycles ； Anticancer Agents

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