- 學位論文
合成及分析合適於熱療法之奈米顆粒
To synthesize and analyze the nanoparticles suitable for hyperthermia purpose
摘要
本實驗為製備及分析合適於熱癌症療法之奈米顆粒。首先，使用乙醯基丙酮鐵-Fe(acac)3和十六烷二醇-1,2-hexadecanediol，以熱解法合成氧化鐵，並加入介面活性劑使其為奈米等級的氧化鐵。可藉由控制介面活性劑的濃度，控制成長出4~25 nm的氧化鐵顆粒。也可藉由置入部分小尺寸氧化鐵奈米顆粒做為核種，成長成較大尺寸顆粒。若加入核種顆粒後，在製程上做變化，可再一反應液中，同時製備出不同大小，顆粒尺寸成二集團分佈的奈米顆粒。 若以乙醯丙酮錳-Mn(acac)3取代乙醯基丙酮鐵，則可合成錳/鐵氧化物奈米顆粒，同時也可藉由置入部分小尺寸氧化鐵奈米顆粒做為核種，成長成較大尺寸錳/鐵氧化物顆粒。 奈米顆粒的尺寸分布，可藉由XRD和TEM分析。而由於氧化鐵奈米顆粒的結構Fe3O4和γ-Fe2O3不易藉由XRD分析而辨別，因此輔以同步輻射吸收光譜，推斷為60 % Fe3O4和40 %的γ-Fe2O3結構。 而錳/鐵氧化物的成分由EDX鑑定，結構經XRD分析，錳原子取代原氧化鐵結構中鐵原子的位置，而晶格的結構不改變。 合成之氧鐵奈米顆粒為超順磁性，但是錳/鐵氧化物奈米顆粒為室溫鐵磁性，且整個磁滯曲線會有位移的現象，推測為奈米顆粒的交換偏移場( exchange bias )現象。 除了氧化鐵奈米顆粒之外，我們同時也嘗試以化學氧化還原法，合成磁性的硼化鐵奈米顆粒，目前仍無法防止奈米等級的顆粒聚集，不過有些實驗經驗，可供作為製備硼化鐵奈米顆粒的參考。
並列摘要
In this thesis, we synthesize and analyze the magnetic nanoparticles suitable for cancer therapy. Fe(acac)3, 1,2-hexadecanediol, and the surfactant were mixed in phenyl ether and heated to reflux to synthesize the iron oxide nanoparticles. We increase and control the particles size from 4 to 25 nm by changing the amount of the surfactant or adding the 4 nm seed particles in. And we change in process; we can synthesize the nanoparticles with two kinds of size. If part of the Fe(acac)3 is substituted by Mn(acac)2, it is iron/manganese oxide nanoparticle. The nanoparticles were analyzed by XRD, VSM, and X-ray absorption spectra and we demonstrated that the structure of the iron oxide is 60 % Fe3O4 and 40 % γ-Fe2O3. It is speculated that MnFe2O4 structure is appeared by adding the manganese precursor. The magnetic filed of the saturation magnetism increased by adding the manganese element. And the center of M-H loops of the iron/manganese nanoparticles would be shifted up to 50 Oe. We speculated that it is a core/shell structure judged from the Mn L-edge, O K-edge absorption spectra. Except the iron oxide nanoparticles, we also try to synthesize the iron boride nanoparticles. Though the iron boride nanoparticles could not be restricted to nanosize, the experimental results could be supplied for reference.