發展具傳遞功能之含硼聚合物應用於硼中子捕獲治療

Development of boron-containing polymeric drug delivery system for Boron Neutron Capture Therapy

謝承穎(Cheng-Ying Hsieh)

指導教授 ： 孫毓璋 ； 許銘華

國立清華大學/原子科學院/生醫工程與環境科學系/碩士(2013年)

https://doi.org/10.6843/NTHU.2013.00598

摘要

台灣自1980年代起，癌症就一直位居國人十大死因之首，癌症難以治療一來是由於其生物變異程度大，二來是術後組織殘餘、沾黏都有可能再次復發，因此傳統上常同時使用手術、化療或放療等來增進其療效；其中放射治療也是很重要的一環，在早期科學家們對劑量掌控能力不佳，因此常造成病人組織潰爛死亡，但近年來隨著工藝技術與醫療技術大幅演進，放療從γ射線、電子、質子、中子演進至今日的重粒子治療等。而從1960年代開始出現的硼中子捕獲療法則是同時結合放療與藥物的一種二元治療方式，其利用含硼藥物吸收中子後核分裂產生的α粒子去摧毀腫瘤細胞，此治療方式的特點來自於含硼藥物或中子射線獨立使用時對人體的傷害十分低，且α粒子在人體內行進距離約為9μm，此距離約與一個細胞的維度相當，也意味著α粒子造成的破壞只會發生在吸收了含硼藥物的癌細胞裡，上述特點大幅提升了硼中子捕獲療法的選擇性，以現今來說治療仍受限於功能有限的含硼藥物上，因此如何合成出同時具有高濃度硼與特定選擇性的藥物是此治療未來發展性與本篇論文所要研究的重點

關鍵字

硼中子捕獲療法

並列摘要

Cancer has been the most cause of death since 1980s in Taiwan. Traditionally, there has many treatments of cancer such as surgery, chemotherapy, radiotherapy. These therapy are directly attack to the tumor cells. Although the killing effect are very well, but they also affect the normal cells even hurt other organs in the body. And if the tumor cells were not clearly been moved from the normal tissue, it may transfer to other place and cause a newly lesions. So the scientists and doctors are looking for a more precise and effect method to kill the tumor cells. Recently, Boron Neutron Capture Therapy ( BNCT ) is a ideal option to cure the cancer.
The boron neutron capture therapy (BNCT) was started since 1936 by Locher, who suggested that two essential issues associated with BNCT: delivery of boron-10
to cancer cell and high quality and sufficient thermal neutron for irradiation. In the 1950s, Sweet started the clinical investigation on glioblastoma multiforme at Massachusetts Institute of Technology (MIT), however, 18 patients passed away from 10 days to 11.5 months after irradiation. 1960s, Hatanaka continued and modified the Sweet’s research work at Tokyo University got promising results in glioblastoma. The first time BNCT treatment in the history did not work out very well because of over-dosage. But due to the improvements of dosage-control and drug delivery system, it is much safer nowadays and become a potential therapy on advanced cancer therapy.

並列關鍵字

BNCT

參考文獻

[1] Lawrence EO. The biological action of neutron rays. Radiology 1937; 29: 313-22.

neutrons on normal and tumor tissue. Proc Nat Acad Sci USA 1936; 22: 543.

[3] Lochner GL. Biological effects and therapeutic possibilities of neutrons. Am J

[4] Barth RF, Joensnu H. Boron neutron capture therapy for the treatment of

glioblastomas and extracranial tumours: as effective, more effective or less effective than photon irradiation? Radiother Oncol 2007; 82 : 119 – 22.