磁性氧化鐵/奈米銀/蠶絲蛋白可降解複合水膠之開發與其於光熱與磁性熱治療之評估

Developing magnetic silver/fibroin thermosensitive hydrogels for application in magnetic hyperthermia and photo-thermal therapy

謝家琪(Chia-Chi Hsieh)

指導教授 ： 楊大毅

中原大學/工學院/化學工程研究所/碩士(2018年)

https://doi.org/10.6840/cycu201800464

摘要

癌症為人類死亡的主要原因之一，在台灣甚至長年位居十大死因之首，因此有許多研究致力於控制癌細胞生長及癌症治療。磁性熱治療即為磁性奈米顆粒因外加交流磁場，而其須對交流磁場作出反應，因而產生能量損耗並以熱的形式散失至癌細胞區域以達到殺死癌細胞的目的；可見光/近紅外光熱療法則為利用材料吸收特定光波長，並轉換為熱能之光熱效應進而破壞癌細胞。此方法對人體其他健康細胞無害，副作用較小，被視為極具發展潛力的癌症治療法。本研究致力於發展磁性氧化鐵/奈米銀與蠶絲複合材料之癌症磁性光熱治療應用。利用合成磁性氧化鐵/奈米銀複合粒子與LED光照的輔助，調控奈米銀之粒徑與形貌，進而獲得可在可見光與近紅外光區間(600nm至900nm)，吸收特定波長之複合粒子。此外，本研究亦將此複合粒子置於蠶絲蛋白內，發展出具各式型態之磁性氧化鐵/奈米銀與蠶絲複合材料，以提升其生物相容性。預期本研究之實驗成果，將有助於癌症磁性及光熱熱療之應用。

關鍵字

高分子複合材料 ； 奈米銀 ； 氧化鐵 ； 光熱治療 ； 磁性粒子熱治療 ； 絲素蛋白

並列摘要

Cancer has been one of the leading causes of human death for centuries. Considerable effort has been devoted to developing new treatments to reduce and control cancers. Magnetic particle hyperthermia and near-infrared photo-thermal therapy are the promising strategies to treat cancers due to its effectiveness with only mild side effects. This study focused on one-step method of synthesizing magnetic iron oxide (Fe3O4)/ silver (Ag) nanoparticles which assisted by capping agents to control the particle’s morphology, hence obtaining optimal hyperthermia performance. Silk fibroin is used to form hydrogels for encapsulating the Fe3O4/Ag particles. The rheological properties of the resultant Fe3O4/Ag/fibroin hydrogels are tuned so that they are in sol-state at room temperature and could be injected into human body with minimal surgical wounds and then become gels in human body. The advantages of the developed Fe3O4/Ag/fibroin composite hydrogels are: low cost material with injectability, preventing nanoparticles from damaging healthy tissues, and multi-functions to treat cancers.

並列關鍵字

polymer composite material, silver nanoparticle, iron oxide, photothermal therapy, magnetic hyperthermia, silk fibroin

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