積木式微流體晶片之研究

大多數實驗室晶片製程都在同樣的基材上完成，本文利用不同基材製作微流道晶片，並將兩者以毛細管接合，已突破以往實驗室晶片的型式，積木式微流道晶片使晶片設計更為靈活，不會受到單一基材的限制，並配合本研究室已開發之微線圈可達到幫浦的效果。本研究是在非無塵室的環境中製作積木式單向閥微流道晶片，大幅降低製作所需之成本，並且以可拋棄的型式為設計概念。此積木式單向閥微流道晶片可應用於生物醫學領域，並且可加入更多的微流體元件而達到更多功能的需求。本研究利用實驗室已開發之三種不同尺寸的微線圈，每個型式分別各以五片晶片實驗來取得平均值。單向閥微流道晶片的最大流率、背壓分別為：線圈12圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量339μl/min、最大驅動背壓3.5 kPa；線圈10圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量220μl/min、最大驅動背壓2.4 kPa；線圈8圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量100μl/min、最大驅動背壓1.8 kPa。單向閥微流道晶片連接磁制動閥微流道晶片的最大流率為：線圈12圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量266μl/min；線圈10圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量169μl/min；線圈8圈在驅動電流500 mA，驅動頻率5 Hz時，最大流量49μl/min。單向閥微流道晶片與磁制動閥微流道晶片可承受之最大壓力分別為：42.5 kPa及21.4 kPa。

關鍵字

微線圈；微流道；積木式單向閥微流道晶片；磁制動閥微流道晶片；實驗室晶片

並列摘要

Most lab-on-a-chip manufacturing process completed on the same substrate, this substrate produced using different microchannel chips, and both the capillary bonding, has exceeded the previous type of lab-on-a-chip, blocks type microchannel chip to chip decline design more flexible, not limited by a single substrate, and with our laboratory has developed micropump coil can achieve the effect. This study was conducted in non-production clean room environment check valve modular microfluidic chip, significantly reducing the cost of production required and the type to be abandoned for the design concept. This check valve modular microfluidic chip can be applied to the biomedical field, and can add more microfluidic components to achieve more functions. In this study, the laboratory has developed three different sizes of micro-coil, respectively, each of the five types of experiments to get the chip average. Check valve microfluidic chip maximum flow rate, back pressure are as follows: For the coil 12 type, the maximum volumetric flowrate of the pump is 339μl/min, and maximum pump pressure is 3.5 kPa, at the excitation current of 500 mA, and the excitation frequency of 5 Hz; For the coil 10 type, the maximum volumetric flowrate of the pump is 220μl/min, and maximum pump pressure is 2.4 kPa, at the excitation current of 500 mA, and for the coil 8 type, the maximum volumetric flowrate of the pump is 100μl/min, and maximum pump pressure is 1.8 kPa. Check valve microfluidic chip connect with magnetic actuator valve microfluidic chip maximum flow rate are as follows: For the coil 12 type, the maximum volumetric flowrate of the pump is 266μl/min, at the excitation current of 500 mA, and the excitation frequency of 5 Hz; for the coil 10 type, the maximum volumetric flowrate of the pump is 169μl/min, at the excitation current of 500 mA, and the excitation frequency of 5 Hz; for the coil 8 type, the maximum volumetric flowrate of the pump is 49μl/min, at the excitation current of 500 mA, and the excitation frequency of 5 Hz. Check valve microfluidic chip and the magnetic actuator valve microfluidic chip can withstand the maximum pressure, respectively: 42.5 kPa and 21.4 kPa.

並列關鍵字

Lab-on-a-chip ； Microchannel ； Blocks type check valve microfluidic chip ； Magnetic actuator valve microfluidic chip ； Microcoil

參考文獻

[1] Xuan-Qi Wang, and Yu-Chong Tai, “A normally closed in-channel check valve,” Proceeding of the IEEE Micro Electro Mechanical Systems, Apr, 2000, p68-73

[2] Jun Xie, Xing Yang, Xuan-Qi Wang, and Yu-Chong Tai, “Surface micromachined leakage proof parylene check valve,” Proceeding of the IEEE Micro Electro Mechanical Systems, Jan, 2001, p539-542

[3] Zunqiang Fan, Jianfang Liu, Jingshi Dong, and Jianqiao Li and Yu-Chong Tai, “Study on the large flow rate piezoelectric mini-pump with metal check valve,” Proceeding of the IEEE Micro Electro Mechanical Systems, Sep, 2009, p4294-4298

[4] Jacob J. Loverich, Isaku Kanno, and Hidetoshi Kotera, “Concepts for a new class of all-polymer micropumps,” Lab on a Chip, Jun, 2006, p1147-1154

[5] JeongYun Kim, JuYeoul Baek, KiHwa Lee, YongDoo Park, Kyung Sun, TaeSoo Lee, and SangHoon Lee, “Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery,” Lab on a Chip, Jun, 2006, p1091-1094

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積木式微流體晶片之研究

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