下肢周邊動脈疾病無線檢測評估系統

Wireless Evaluating System for Peripheral Arterial Disease of Lower Limbs

呂紹弘(Shao-Hung Lu)

指導教授 ： 蔡正倫 ； 林康平

中原大學/工學院/生物醫學工程研究所/碩士(2017年)

https://doi.org/10.6840/cycu201700818

摘要

周邊動脈疾病發病的時間隨著年齡呈現急遽的上升，隨著病情演進，此疾病與截肢、中風與心肌梗塞有著非常大的關聯，人體下肢因為重力影響是血液回流最困難的地方，所以血管內容易堆積斑塊，並可以視為全身性動脈阻塞的先期徵兆。
肌肉中的氧濃度變化與供應氧氣的動脈血流通暢與否有很直接的關係，使用近紅外光譜儀量測運動之後下肢肌肉氧濃度回復速度可以來幫助判斷周邊動脈是否阻塞。
此研究製作了一套無線穿戴式的肌肉含氧量變化檢測系統，使用三個波長的近紅外光深入穿透進入肌肉組織中的光路徑差來量測肌氧濃度值在運動時以及運動後的變化量，並用以計算肌氧濃度在運動後的回復速率。使用此系統在正常人實施間歇性的踮腳尖運動時，實際測量的結果顯示運動與休息時的血液灌流量變化，以及所計算的肌氧濃度變化都能符合生理反應上該有的代償作用，所得到的肌氧濃度訊號變化也屬於合理的生理範圍。

關鍵字

周邊動脈阻塞疾病 ； 近紅外光譜儀 ； 踮腳尖實驗 ； 代償作用

並列摘要

The incidence of peripheral arterial disease greatly arise with age. The disease also has a strong correlation with amputation, stroke and myocardial infarction. The back flow of blood from lower limbs is the most difficult because of the gravity. Therefore, blood plaque tends to start accumulating in the blood vessel of lower limbs. Such an occlusion can be regarded as an early sign of systemic arterial obstruction.
The oxygenation of myoglobin is directly related to the supply of oxygen by arterial blood flow. By using near-infrared spectroscopy to measure the recovering rate of oxygenation in lower limbs, it will be helpful to know whether peripheral arteries are blocked.
In this study, a wireless wearable system was developed to measure the change in myoglobin oxygen concentration. By measuring the light absorption of near-infrared at three different wavelengths traveling through muscle tissue, it can decompose the change in myoglobin and oxy-myoglobin during exercise. The measurement results on normal human subjects matches well with the compensatory effect during a periodic tip toe calf exercise. The evaluated recovery rate of myoglobin oxygenation after stopping exercise is relatively stable within a reasonable physiological range. This shows a possibility of using this measuring system to evaluate the peripheral arterial disease of low limbs.

並列關鍵字

Peripheral arterial occlusive disease ； Near-infrared spectroscopy ； Tip toe calf exercise ； Compensatory effect

參考文獻

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