金針根部化學成分之研究

Phytochemical Studies on the Roots of Hemericallis fulva Linn

周芳華(Fang-Hua Chou)

指導教授 ： 謝博進

中原大學/理學院/化學研究所/碩士(2001年)

https://doi.org/10.6840/cycu200100352

摘要

金針 (Hemericallis fulva Linn.) 為百合科 (Liliaceae) 植物，其根部具有利水、涼血、抗瘧疾之功效，用於治療水腫、黃疸、便血。將金針根部曬乾後，以95 % 乙醇浸泡，經過濾、減壓濃縮後得乙醇抽出物，再以乙酸乙酯與水萃取。將乙酸乙酯抽出物濃縮後以矽膠管柱層析、薄層色層分析等過程進行分離純化，得到10個化合物，經光譜資料之分析，鑑定其結構均為anthraquinone類化合物，分別為aloesaponarin Ⅱ (1), chrysophanol (2), obtusifolin (3), 8-hydroxy-1-
methoxy-3-methyl-anthraquinone-2-O-β-D–glucoside (4), 7-hyrdoxy-
3-methyl-1,2,8-trimethoxy-anthraquinone (5), 7,8-dihydroxy-1,2-
dimethoxy-3-methyl-anthraquinone (6), 3,8-dihydroxy-1-methyl-
anthraquinone-2-carboxylic acid (7), aloe-emodin (8), 1,2-dimethoxy-8- hydroxy-3-methyl-anthraquinone (9), 8-O-methylchrysophanol (10)。其中三個化合物 4, 5, 6 為首次發現之天然物。

關鍵字

金針

並列摘要

The roots of Hemericallis fulva Linn (Liliaceae) is used as anti-malarial .
The roots of Hemericallis fulva were extracted with 95 % EtOH. After evaporation of solvent, the concentrated EtOH extract was partitioned between H2O and EtOAc. By means of various column chromatographic separation, ten compounds were isolated from the EtOAc fraction. Using spectral analysis and chemical reaction ,they were identified as anthraquinone aloesaponarin Ⅱ (1), chrysophanol (2), obtusifolin (3), 8-hydroxy-1-methoxy-3-methyl-anthraquinone-2-O-β-D-
glucoside (4), 7-hydroxy-3-methyl-1,2,8-trimethoxy-anthraquinone (5),
7,8-dihydroxy-1,2-dimethoxy-3-methyl-anthraquinone (6), 3,8-
dihydroxy-1-methyl-anthraquinone-2-carboxylic acid (7), aloe-emodin (8), 1,2-dimethoxy-8-hydroxy-3-methyl-anthraquinone (9),8-O-
methylchrysophanol (10). Among these ten compounds, compounds 4, 5, 6 were new nature products.

並列關鍵字

Hemerocallis fulva

參考文獻

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4.Takemoto, T.;.Kusano, G. The constituents of Hemericallis. I. Constituents of H. logituba. l . Yakugaku Zasshi 1966, 86, 1116-1119.

6.Inoue, K.; Konishi, T.; Kiyosawa, S.; Fujiwara, Y. 2,5-Dihydrofuryl-γ-lactam Derivatives from Hemericallis fulva L. var. kwanso REGEL. Ⅱ. Chem. Pharm. Bull. 1994, 42, 154-155.

7.Konishi, T.; Inoue, T.; Kiyosawa, S.; Fujiwara, Y. A 2,5-Dimethoxytetrahydrofuran from Hemericallis fulva var. kwanso . Phytochemistry 1996, 42, 135-137.