中 文 摘 要 本研究中我們希望能發展有效製備β-位置具氫氧基或甲氧基之烷基咪唑或三唑類化合物。 首先我們採用N-溴代丁二醯亞胺和α-甲基苯乙烯或苯乙烯進行加成反應,將所得的溴甲氧基反應或溴氫氧基化反應的產物再和咪唑試劑或三唑試劑反應,即可得到我們想要的產物。 目前已合成出來的化合物有1-imidazol-1-yl-2-phenyl- propan-2-ol,2-imidazol-1-yl-1-phenyl- ethanol,1-(2-methoxy- 2-phenyl-propyl)-1H-imidazole,1,2,4-triazol-1-yl-2-phenyl- propan-2-ol。
Abstract In this research, we hope to develop an efficient method to prepare alkyl imidazoles or triazoles with β-hydroxy or β-methoxy substituents. First, styrenes undergo bromohydroxylation or bromomethoxylation to obtain 1-phenyl-2-bromoethanol, 1-bromo-2-phenyl-2-propanol, 1-Methoxy-1-phenyl-2-bromoethane, or 1-bromo-2-methoxy-2-phenyl propane. These compounds then react with imidazole or triazole to obtain the desired products. At present, 1-imidazol-1-yl-2-phenyl-propan-2-ol, 2-imidazol-1-yl-1- phenyl- ethanol, 1-(2-methoxy-2-phenyl-propyl)-1H-imidazole, 1,2,4- triazol-1-yl-2-phenyl-propan-2-ol have been synthesized.