- 學位論文
利用溶膠-凝膠法製備毛細管電層析管柱之研究
Preparation and Application of Sol-Gel Monolithic Column for Capillary Electrochromatography Column
摘要
研究溶膠-凝膠反應的產物在特定製備過程下將形成或塊狀固體，而其中塊狀固體可經由適當的乾燥過程將轉變成多孔洞材料。藉由實驗條件或步驟的改變若能形成外觀、尺寸不同的多孔洞材料，這將會非常適合當作毛細管內的填充材料。 實驗將多次調整製作程序、反應時間與觸媒濃度的控制來形成不同外觀的填充物。依據電子顯微鏡的高放大倍率來觀察不同製作程序的填充物外觀，並找出製作最合適當作毛細管電層析靜相尺寸與外觀製作程序與條件。 此外利用溶膠-凝膠反應過程中摻雜含苯基物質，藉由溶膠-凝膠反應的特性將固定相銜接苯基，並以材料分析方式確定苯環鍵結於溶膠-凝膠反應生成物。 對苯基的樣本分析物進行滯留與分離的討論，同時以最合適外觀及尺寸之填充毛細管柱，進行對含苯基的混合物的分離。
並列摘要
The product of sol-gel reaction can be transformed to densefilm or monoliths through certain process and sometime the monoliths can also be changed into porous material via proper extraction. If the adjustment of condition parameter or procedure can result in different outlined and dimensioned porous material, it will be a proper material for filling in capillary column. Based on the observation on the morphology of packing column in different process, we are able to obtian the most proper procedure for making stationary phase of capillary electrochromatography . Moreover, by adding phenyl substance in the sol-gel reaction, the stationary phase of bonding phenyl group occurred is achieved . A series of material is used in order to analyses examine the bonding ability of phenyl group on the sol-gel monolith. The separation and retention behaviors of several phenyl compounds on the sol-gel CEC column was examined. The influence of the morphology of the sol-gel stationary phase on the separation was also evaluated of the tested compounds.
參考文獻
延伸閱讀
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