混合電荷類雙離子性感溫型水凝膠之製備及其生物相容性質研究

Preparation of Pseudozwitterionic hydrogels with thermoresponsive control for the study of theirs biocompatibility

鄭永昇(Yong-Sheng Zheng)

指導教授 ： 張雍

中原大學/工學院/化學工程研究所/碩士(2010年)

https://doi.org/10.6840/cycu201000834

摘要

中文摘要
發展與人體組織接觸之生醫材料，對於其材料表面抵抗非專一性生物分子吸附的控制為非常重要的一個環節。本研究欲發展感溫型之低生物沾黏性生醫材料，未來可應用於藥物釋放、生物感測與組織阻隔膜的開發。在分子結構設計方面，本研究將製備含類雙離子性之感溫型聚丙基丙烯醯胺水凝膠系統，並探討其生物相容性質。
本研究以比例為1:1之正負電荷單體，使用自由基交聯聚合方法製備出不同含量之類雙離子性感溫型聚丙基丙烯醯胺水凝膠。研究中觀察類雙離子性感溫型水凝膠之物理性質及化學特性，並系統性探討其與蛋白質、血球及細菌之沾黏行為。

關鍵字

水膠 ； 感溫型 ； 聚丙基丙烯醯胺

並列摘要

英文摘要

The control of nonspecific biomolecular adsorption on the material surface is an important stage to develop the human tissue contacting biomaterials. In this work, we designed a thermoresponsive materials with low bioadhesive control in the applications of drug delivery, biosensing, and anti-bioadhesive membranes. In the consideration of molecular structure design, the study described a novel pseudozwitterionic hydrogel containing thermoresponsive N-isopropylacrylamide (NIPAAm) and investigated its biocompatibility.
In this work, thermoresponsive polyNIPAAm gels containing 1:1 molar ratio of positively charged TMA and negatively charged SA were prepared using free radical polymerization. The copolymeric hydrogels exhibited controllable temperature-dependent swelling behaviors and showed stimuli-responsive phase characteristics in the presence of salts. The interactions of these hydrogels with biomolecules and microorganisms were demonstrated by protein adsorption, and bacterial attachment, which allowed us to evaluate their bioadhesive properties.

並列關鍵字

hydrogel ； thermoresponsive ； NIPAAm

參考文獻

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