洛神花、綠藻及苦瓜組成之複合食材改善胰島素阻抗之研究

Study on the insulin-resistance improving effect of the combinational food consisting of roselle, green algae and bitter melon

劉運豪(Yun-How Liu)

指導教授 ： 吳亮宜

中原大學/工學院/生物科技研究所/碩士(2012年)

https://doi.org/10.6840/cycu201400204

摘要

近年來由於人們飲食習慣改變，許多現代食物變的會導致人們容易罹患胰島素阻抗、代謝症候群以及代謝症候群相關慢性疾病，如高血壓、心血管疾病以及第二型糖尿病等等。因此如何吃的營養又健康便成了每個人的重要課題。本實驗的目的在評估由洛神花、綠藻及苦瓜組成之複合健康食品改善胰島素阻抗及代謝症候群之效果。
本實驗選用SD 雄性大鼠並分成四組，分別是空白組 (B)：餵食一般飼料；控制組 (C) ：餵食60%高果糖飼料；食材處理組1 (T1) ：餵食混有洛神花1%、綠藻0.8%以及苦瓜0.1%之60%高果糖飼料；食材處理組2 (T2) ：餵食混有洛神花0.5%、綠藻0.4%以及苦瓜0.1%之60%高果糖飼料。本實驗持續10週，實驗期間分析血壓、禁食血糖、胰島素、三酸甘油酯、總膽固醇以及進行口服葡萄糖耐受性測試。
實驗結果顯示， C 組之大鼠餵食高果糖飼料後造成禁食血漿葡萄糖、胰島素、三酸甘油酯、膽固醇濃度及收縮壓顯著增加，另外在口服葡萄糖耐受性測試中則發現 C 組大鼠之血漿葡萄糖與胰島素濃度之曲線下面積皆顯著大於 B 組；此結果顯示 C 組 大鼠產生了胰島素阻抗之現象。相較於 C 組， T1 及 T2 組在收縮壓、禁食血漿葡萄糖、葡萄糖耐受性以及胰島素阻抗皆有改善之現象，顯示本實驗使用之洛神花、綠藻及苦瓜組成之複方能改善胰島素阻抗及代謝症候群之現象。

關鍵字

胰島素阻抗 ； 苦瓜 ； 洛神花 ； 綠藻

並列摘要

Due to the dietary habits changed, lots of modern dietary behaviors cause people vulnerable to insulin-resistance, metabolic syndrome and metabolic syndrome related chronic diseases such as hypertension, cardiovascular disease and type 2 diabetes. However, in the world full of artificial chemical compounds, how to eat healthier and nutritious has become a primary lesson to everyone. Purpose of this study is to evaluate the effect of improving insulin resistance and metabolic syndrome by the combinatorial food consisting of roselle, green algae and bitter melon.
In this study, male Sprague-Dawley rats were divided into four groups: the basal group (B) fed with chow; the control group (C) fed with 60% high fructose diet; the treatment 1 group (T1) fed with 60% high fructose diet plus 1% roselle extract, 0.8% green algae extract and 0.1% bitter melon extract and the treatment 2 group (T2) fed with 60% high fructose diet plus 0.5% roselle extract, 0.4% green algae extract and 0.1% bitter melon extract. The study lasted for 10 weeks. Blood pressure, fasting plasma glucose, insulin, triglyceride, total cholesterol and the response of oral glucose tolerance tests (OGTT) were analyzed.
Our data showed that high fructose feeding led significant increase in fasting plasma glucose, insulin, triglyceride, cholesterol and systolic blood pressure in group C. According to the result of OGTT, we also found that the Area Under Curve of plasma glucose and insulin in group C were larger than that in group B, and suggested that high fructose diet induced insulin resistance in group C. Compared to group C, systolic blood pressure, fasting blood glucose, glucose tolerance and insulin resistance were improved in group T1 and T2. According to the results of our study, the combinatorial food consisting of roselle, green algae and bitter melon may ameliorate insulin resistance and metabolic syndrome in fructose fed rats.

並列關鍵字

insulin resistance ； bitter melon ； rosell ； green algae

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