建構周邊血管壓力體積圖量測系統

本研究利用阻抗描記法的方式，配合連續低壓血壓量測裝置，建構出能夠用非侵入的方式去得到血壓訊號以及阻抗變化訊號。阻抗變化訊號利用環狀電極將高頻、低強度之定電流源導入肢體部位，測量周邊血管在每次心跳時血液流經血管的阻抗訊號，再利用阻抗變化與體積變化成正比之關係去推算血管體積變化。有了血壓和體積，便可以畫出壓力體積圖(PV-loop)，從先前的研究可以知道左心室的壓力體積圖包含了許多心臟功能方面的特徵點，因此本次研究利用此原理去討論周邊血管的壓力體積圖。本研究對12位受測者進行周邊血管阻抗以及血壓的測量，再讓受測者進行冰水造成之升壓反應(cold pressor test)實驗，讓受測者左腳浸泡在冰水中，記錄周邊血管受到刺激時的壓力以及阻抗變化，結果顯示壓力體積圖有如預期的結果在受到刺激時有收縮之現象，而且可以得到壓力體積變化情形之下，也能用來探討周邊血管之順應性以及評估周邊血管特性，算是相當簡單解直接的測量方式。

關鍵字

壓力體積圖；周邊血管

並列摘要

This study proposes to construct a system to obtain blood pressure and impedance signal using non-invasive impedance device and continuous blood pressure measurement device. We acquire impedance signal using ring electrode system to feed high-frequency, low- intensity constant current source into subject’s forearm. It measures beat-to-beat impedance signal originated from the blood flow though the peripheral vessel. We then used the positive relationship between the impedance change and the volume to obtain the vessel volume change. Equipped with information of pressure and volume, we could plot the pressure-volume loop. It is known that the left ventricular pressure-volume loop contains a number of feature points indicating the performance of cardiac function. Therefore, in this study, the same principle is used to discuss the peripheral vessel pressure-volume loop. In this study, impedance signal of the peripheral blood vessel and blood pressure waveform were obtained from twelve young volunteers, using the custom-made system. The subjects went through the cold pressor test by immerging the subject’s left leg in the ice water. The blood pressure and impedance changed were recorded. The results illustrated that the pressure-volume loop, as it was expected, demonstrated the contraction phenomenon after stimulation. Additionally, it is a easy measurement that can be used to investigate the compliance and characteristic of peripheral blood vessel.

並列關鍵字

pressure-volume loop ； peripheral blood vessel

參考文獻

[17] 張峰碩,”建構非侵入式連續血壓量測系統以評估血管系統之數學模型”,中原大學碩士論文民國94年7月。

[2] Ding chang Zheng, Alan M. ＂Non-invasive quantification of peripheral arterial volume distensibility and its non-linear relationship with arterial pressure＂Journal of Biomechanics 42 1032–1037,2009

[3] Peckerman A, Saab PG, McCabe PM, Skyler JS, Winters RW, Llabre MM, Schneiderman N. “Blood pressure reactivity and perception of pain during the forehead cold pressor test”,Psychophysiology. Sep;28（5）:485-95, 1991

[4] Peckerman A, Saab P., Llabre M., Hurwitz B., McCabe P, and Schneiderman N.“Cardiovascular and Perceptual Effectsof Reporting Pain During the Foot and Forehead Cold Pressor Test”, Intrnational journal of behavioral medicine, 5(2), 110~ 117 , 1998

[5] Hurwitz B. , Saab P. , Llabre M., Schneiderman N. “The cold pressor test Vascular and myocardial response patterns and their stability” , Psychophysiology,30,366-373 , 1993

國際替代計量

建構周邊血管壓力體積圖量測系統

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