功能性水凝膠製備及其性質研究

Design and Preparation of Functional Hydrogels and Investigation Their Properties

褚翌佐(YI-ZUO CHU)

指導教授 ： 葉美鈺

中原大學/理學院/化學系/碩士(2022年)

https://doi.org/10.6840/cycu202201329

摘要

水凝膠在近年來的創新發展使其成為一個非常具有潛力的新興材料，根據不同的配方所製備出來的水凝膠會有不同的特性，因此可以應用於各式各樣的領域中，而其中生物醫材的水凝膠是我們致力於研究的方向。
在本篇論文中，我們設計使用丙烯醯胺單體，再加上三種環糊精和二醛官能化聚乙二醇(DF-PEG)的苯環有主-客體作用力，最後加入具有四苯環結構的Py-HEMA，我們使用了拉力試驗機、流變儀和SEM去證實了膠體的機械強度，也使用了核磁共振去證實了Beta-環糊精作為主體的主-客體作用力最強，此種水凝膠展現了高強應力以及拉伸性且具有螢光特性，是極具潛力的材料。
接著我們將Beta-環糊精和不同分子量的DF-PEG引入天然物幾丁聚醣水凝膠中，利用氫鍵和希夫鹼鍵(Schiff Base)形成動態的化學鍵，配置成自癒合水凝膠，我們將此種水凝膠應用於注射的測試中，發現其擁有良好的自癒合和注射性，對於未來生物墨水有很好的潛力。

關鍵字

水凝膠

並列摘要

The innovative development of hydrogels has recently made them a promising emerging material. According to different formulations, hydrogels have other properties and can apply in various fields, such as bioelectronics, biomedical, soft sensor and so on. Among them, we are interested in developing functional hydrogels for biomedical applications.
In the first part of this work, we investigated the effect of the ring size of cyclodextrins (CDs) on their host-guest interactions with benzene rings. Moreover, pyrene was incorporated to provide fluorescence in the hydrogel systems. We used a tensile tester, rheometer and SEM to confirm the mechanical strength and microstructures of the hydrogels. It was found that beta-cyclodextrin exhibits the strongest host-guest interaction with benzene rings. This hydrogel shows high stress, stretchability, and good adhesion properties, making them promising materials for wearable sensor applications in healthcare.
Next, we prepared chitosan-based hydrogels and studied beta-cyclodextrin with different molecular weights of dialdehyde-functionalized polyethylene glycol (DF-PEG). Hydrogen and Schiff base bonds form dynamic chemical bonds and are the self-healing mechanisms of hydrogels. We applied them to the injection test and found that they have good self-healing and injectability, thus making them the potential of scaffolds and bioinks in biofabrication and tissue engineering.

並列關鍵字

hydrogel

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