Data reduction in data mining is very important when we are dealing with large datasets. Through data reduction, we can increase storage efficiency and reduce the run time of data mining process. One of the methods is to reduce the volume of data and selectively retain a subset of the dataset as the representation of the original one. This method is known as prototype selection (Olvera et al, 2008). Prototype selection aims to discard the superfluous instances in training set, because superfluous instances affect the results in data mining. In this thesis, we propose a hybrid prototype selection method using clustering algorithm and selected the most relevant subset of cluster members, called CLU-R algorithm. The results showed that the CLU-R algorithm performed better than the original methods used individually.