鞘芯型聚二甲基矽氧烷複合纖維膜製備與其在自摺疊之應用

癌症為人類死亡主因之一，對於癌症治療的問題，學術界積極尋找新的治療技術，期望能減少病患痛苦，並降低副作用。磁性熱治療與光熱治療是目前最具潛力的癌症治療技術。有鑑於此，本研究以具有良好生物相容性之聚己內酯(PCL)，包覆氧化鐵(Fe3O4)奈米粒子、普魯士藍(Prussian blue)奈米粒子，結合具有良好延展性之聚二甲基矽氧烷 (PDMS)，發展出同軸靜電紡絲磁性複合纖維材料，使其可應用於癌症磁性熱治療與光熱治療技術。本實驗包含: 1. 利用水熱法合成出磁性氧化鐵奈米粒子(Fe3O4)，並利用界面活性劑聚乙烯吡咯烷酮(PVP)，控制磁性氧化鐵奈米粒子的粒徑大小，增強其在溶液中分散性。接著探討聚己內酯(PCL)、聚二甲基矽氧烷 (PDMS)同軸靜電紡絲型態，製備出磁性奈米纖維複合材料，並在高頻率交流磁場下，探討磁性複合纖維膜對加熱效果之影響及型態變化; 2.合成普魯士藍奈米粒子，並結合聚己內酯、聚二甲基矽氧烷成為同軸靜電紡絲型態，製備出奈米纖維複合材料。再利用其吸收700 nm區間紅光之特性，研究不同波長與激光功率，對材料升溫效果之影響。預期本研究之實驗成果，將有助於癌症熱治療及光熱治療之應用。

關鍵字

磁性熱療法；光熱治療法；同軸靜電紡絲；普魯士藍；聚二甲基矽氧烷

並列摘要

Cancer is one of the main causes of human death. Many academic researchers are actively looking for new therapeutic technologies that can help to reduce the pains of patients and the side effects. Currently, magnetic hyperthermia and photothermal therapy are the most potent cancer treatment technology. Therefore, this study utilizes biocompatible polycaprolactone (PCL), iron oxide (Fe3O4) nanoparticles, Prussian blue (PB) nanoparticles and ductile polydimethylsiloxane (PDMS) to develop co-axial electrospun composite fibers that can be applied on the magnetic hyperthermia and photothermal therapy cancer treatment. This study synthesized magnetic Fe3O4 nanoparticles using a hydrothermal method. Polyvinylpyrrolidone (PVP) was introduced to control the particle size and to improve the dispersibility of nanoparticles in solution. Next, the morphology of the electrospun Fe3O4/PCL/PDMS composite fibers were systematically investigated and their heating performance was evaluated under alternating electromagnetic field. Furthermore, electrospun PB/PCL/PDMS composite fibers were also developed and their heating performance was studied by exposing to visible red light with a wavelength near 700nm. These results are expected to contribute the advance of hyperthermia and photothermal therapy.

並列關鍵字

Magnetic hyperthermia ； photothermal therapy ； Co-axial Electrospinning ； Prussian blue ； Polydimethylsiloxane

參考文獻

1. F. Bray , J. Ferlay , et al. , Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancer in 185 countries, CA Cancer J Clin ,2018.68(6):p.394.

Google Scholar

2. S. Mornet , S. Vasseur , F.Grasset , E.Duguet , Magnetic nanoparticle design for medical diagnosis and therapy, Angew. Chem. Int. Ed. Engl. ,2004.14:p.2161.