At present, the application of artificial intelligence in the industry is getting better and better, the amount of data is becoming more and more, and it is necessary to improve production efficiency and reduce costs to bring competitiveness. Therefore, this study uses the data of the CNC machine as the background, using three different methods, namely neural network, Taguchi method and Taguchi combined neural network, to explore the accuracy of the predicted target value. The actual cut value is used as the data of the neural network training, and then the parameters are used in the Taguchi method. The Taguchi method is used for parameter optimization, and the measured value is used as the actual value through the optimized parameter combination, and the accuracy is compared in three different ways. The final experimental result is the most accurate value predicted by the combination of Taguchi and the neural network. A value of 0.044, less than 5%, which is acceptable to the general industry.