金屬有機骨架核殼微球的製備及層析靜相材料應用研究

The study of metal-organic framework core-shell microspheres fabrication and its application of chromatographic stationary phase

魏文忠(Wen-Zhong Wei)

指導教授 ： 林嘉和 ； 劉婉舲

中原大學/理學院/化學研究所/碩士(2019年)

https://doi.org/10.6840/cycu201900251

摘要

本論文主要探討金屬有機骨架材料-二氧化矽核殼微粒的合成及應用於液相層析靜相之研究，研究中討論二氧化矽羧基改質方法不同與複合材料合成與否的關係及金屬有機骨架合成條件影響單分散與均勻性之效果。論文中呈現傅立葉紅外線光譜圖、掃描式電子顯微光學圖及粉末式X光繞射圖鑑定材料的合成及性質，隨後，將其應用至液相層析靜相中進行三種農藥標準品(Diuron、Isoproturon及Pymetrozine)的分離，希望此靜相材料能提供優異的分析效能。
　　由實驗結果可知，本實驗所製備之ZIF-8@SiO2核殼微球可經由不同條件影響材料的合成成效，此材料所製備的層析管柱背壓低並可以快速分離樣品從而表明二氧化矽的良好填充性能和ZIF-8奈米晶體分離能力的協同效應於層析靜相材料的發展具有潛力。

關鍵字

金屬有機骨架 ； 二氧化矽 ； 核殼微粒 ； 靜相 ； 高效液相層析

並列摘要

In this study, the synthesis conditions of MOF@SiO2 core–shell microspheres composites and its application in high‐performance liquid chromatography stationary phase are mainly discussed. The relationship between the different carboxylate modifications and the synthesis of composites, and the MOF synthesis condition effects for monodispersity were investigated. Herein, Fourier transformation infrared spectrometry, scanning electron microscopy and the powder X-ray diffraction were used to identify the materials synthesis and properties. Subsequently, the synthesized material was applied to the liquid chromatography stationary phase for separating three pesticide standards (Diuron, isoproturon and pymetrozine) and expected for providing good efficiency
From the results, the synthesized performance of ZIF-8 @ SiO2 core-shell microspheres was affected by different methods and the ZIF‐8@SiO2 core–shell microsphere packed column could provide a fast and high‐resolution separation of pesticides as well as low column backpressure that was indicating the synergistic effects of the good column packing properties of the silica spheres and the separation ability of ZIF‐8 nanocrystals. As a result, the preparation of MOF‐based composites are potential materials in separation field.

並列關鍵字

Metal Organic Frameworks ； silica ； core-shell microspheres ； stationary phase ； HPLC

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