以磁場控制包覆油酸之四氧化三鐵奈米粒子應用於油脂清除之研究

動脈硬化之循環系統疾病產生原因為高血脂症所引起，高血脂症是指血液中的脂肪質超過許可的正常範圍，當血脂中有過量的低密度脂蛋白，其含有大量的脂肪及膽固醇，血液流動之過程中會在血管壁堆積乳糜微粒，將會出現粥狀動脈硬化的病變。故本研究擬整合交變與靜態磁場，建構一套可於血管內誘發磁性材料產生動能的磁性操控技術與系統，以達到清除血脂之目的。磁控機構係使用交流電電磁鐵與永久磁鐵，使四氧化三鐵磁性材料產生旋轉和平移運動，並透過輸入電流值調整材料轉速，以達到清除血脂之效能。四氧化三鐵奈米粒子具高生物相容性及超順磁性，囿於其表面具有親水性，實際應用清除脂肪組織時無法突破油水界面，故將奈米粒子包覆油酸使其由親水性轉為親油性。本實驗利用共沉法製備四氧化三鐵奈米粒子，其粒徑為10-15nm，以化學包覆油酸的方式包覆奈米粒子，包覆後粒子的粒徑為100nm~142nm，透過外部磁控即可將粒子導引至待清除區域，再開啟交變震盪磁場，其磁場強度為1000~1200 A m-1，使粒子接觸脂肪沿著磁力線旋轉產生剪應力破壞脂肪。實驗結果顯示，油酸包覆磁性奈米粒子確實可突破油相之界面張力，再透過磁控產生旋轉作用力即可使脂肪組織崩解，此成果初步證實利用本研究之磁性操控技術可達到脂肪清除之功能。

關鍵字

四氧化三鐵；奈米粒子；磁場控制；油酸

並列摘要

The critical role of surfactants in functionalizing nanoparticles is actively studied. This research have shown that bare magnetic Fe3O4 nanoparticles in suspension can be navigated in low gradient and oscillating magnetic field. Microablation of fat in microchannels has been demonstrated. However, steering the nanoparticle movement through fat occlusion has remained difficult even with increased magnetic field strength. Further, the constant exposure to the external field has led to nanoparticle aggregation, a condition that can exacerbate the occlusion. The Fe3O4 nanoparticles are modified in this study by applying oleic acid (OA) as the surface coating to address these challenges. The nanoparticles are synthesized by co-precipitation method and dispersed in organic solvent before mixing with OA. The properties of OA-coated Fe3O4 nanoparticles are characterized for their magnetization, agglomeration, and particle size distribution. The surface-modified Fe3O4 is prepared in suspension and injected into a microchannel to demonstrate that it can be driven through an oil-phase barrier. After coating particles of diameter of 100nm~142nm .An AC magnetic field is used to induce magnetic torque for rotation and a static gradient field to control the translation. The fat microablation process of the surface-modified Fe3O4 is investigated using oscillating field strength of 1000~1200 A m-1. This results shows that the research function of magnetic control technology of fat clearance can be achieved.

並列關鍵字

Fe3O4 ； nano-particles ； magnetic control ； oleic acid

參考文獻

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以磁場控制包覆油酸之四氧化三鐵奈米粒子應用於油脂清除之研究

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