開發人工牙根表面活化之噴射式大氣低溫電漿系統

植牙已是目前缺牙病患最主流的術式，雖然植牙成功率很高但還是有將近一成的失敗率，失敗的原因中最常發生的就是病患骨整合失敗，影響骨整合能力的關係與人工牙根的表面能有關，而改善人工牙根表面親水性亦能增加其表面能。根據文獻，大氣低溫電漿施打在物體表面，能活化物體表面的親水官能基，因此可增加物體表面其親水性，也因未造成人工牙根原有特性破壞，對於FDA標準無須重新認證，讓本研究對於臨床使用更加便利，本研究已開發一人工牙根表面活化之噴射式大氣低溫電漿系統，目的在於改善人工牙根的親水性進而提升其骨整合能力，藉以提高植牙手術成功機率，本研究所使用的噴射式大氣低溫電漿系統，為自行開發的一組電漿系統，包含以氦氣激發，與自製電源供應器及反應器，此系統使用的工作電壓為32kV與工作頻率為126.2kHZ，此情況下所激發的電漿，在氣體流量4 slpm時，電漿激發長度為30 mm，激發過程中最高溫度為35.3oC，本研究證實鈦金屬表面在經由電漿處理60秒後可讓其表面接觸角明顯降低，再根據楊氏熱力平衡方程式，得出接觸角角度越小表面表面能越大，而表面能越大親水性越強，親水性越強人工牙根骨母細胞附著力越強，進而提高手術成功率，本研究已找出此電漿系統最佳參數，且藉由SEM的拍攝證實鈦金屬表面會遭受破壞，未來本研究所開發出之人工牙根表面活化之噴射式大氣低溫電漿系統，可實際於牙科臨床應用。

關鍵字

噴射式大氣低溫電漿；人工牙根；接觸角

並列摘要

Implant has been the major method to treat patient suffered from lacking of tooth. It is still with 10% of failure even though its percentage of success is very high. The failure reasons which occurs most frequently is failure integration between patient’s bone and the new tooth. Then, the surface energy of artificial tooth roots influences the ability of integration, and we can improve the surface hydrophilic ability of artificial tooth roots to increase surface energy. According to papers, when cold atmospheric pressure needle plasma irradiates surface, it will activate its hydrophilic functional group on surface. Therefore, we can utilize this method to increase the surface hydrophilic ability without damage to the original characteristic of artificial tooth roots, so that we don’t have to reauthenticate to FDA. It is more convenient for us to research on clinic. In the study, we have developed a cold atmospheric pressure needle plasma jet-like system with activation of artificial tooth roots in order to increase the integration ability by improving the surface hydrophilic ability of artificial tooth roots. With it, we can raise the success rate of implant surgery. The plasma system we use in the research is developed by ourselves, including stimulation by helium, the power supply and the reactor. The operating voltage of this system is 32 kV and the operating frequency of it is 126.2 kHZ. In this situation, the length of the stimulated plasma will be 30 mm when the flow of gas is 4 slpm. In the process of stimulation, the highest temperature will be 35.3 ⁰c. In the study, we verify that the contacted angle will decrease obviously when the titanium surface is irradiated by plasma for 60 seconds. Then, based on Young’s equation, we can deduce that the surface energy will be higher when the contacted angle becomes smaller. With the higher surface energy, the surface hydrophilic ability will be better. Last but not least, we can raise the success rate of surgery because when the surface hydrophilic ability becomes higher, the adhesion of artificial tooth root osteoblast will be stronger. In the study, we have found the best parameter of the plasma system, and we verify that the titanium surface will be destroyed by SEM. In the future, the cold atmospheric pressure needle plasma system will be applied on dental clinic.

並列關鍵字

Cold Atmospheric-Pressure Plasma-Jet ； artificial tooth root ； Contact angle

參考文獻

[ 2 ]李長祐曲國田”植牙失敗案例之探討及處置－病例報告”Chin Dent J（中華牙誌）25(3)：220-226 September 2006

[ 3 ]D. Buser, N. Broggini, M. Wieland, R. Schenk, A. Denzer, D. Cochran, B. Hoffmann, A. Lussi, S. G. Steinemann. Enhanced bone apposition to a chemically modified SLA titanium surface. J. Dent. Res. 83 (7) 529–533 (2004).

[ 4 ]Prashanth J Rao, MS, Matthew H Pelletier, PhD, William R Walsh, PhD, Ralph J Mobbs, MS, FRACS “Spine Interbody Implants: Material Selection and Modification, Functionalization and Bioactivation of Surfaces to Improve Osseointegration” Orthopaedic Surgery Volume 6 • Number 2 • May, 2014

[ 10] 陳彥政, "電弧放電之研究及應用," 國立成功大學化學工程研究所碩士論文, 2004.

[ 11] M. Wang, B. Holmes, X. Cheng, W. Zhu, M. Keidar, and L. G. Zhang, "Cold atmospheric plasma for selectively ablating metastatic breast cancer cells," PloS one, vol. 8, p. e73741, 2013.

國際替代計量

開發人工牙根表面活化之噴射式大氣低溫電漿系統

未授權

主題瀏覽